机构：[1]Department of Oncology, Tongren Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, P.R. China[2]Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, P.R. China[3]Department of Laboratory Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, P.R. China[4]School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong[5]Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden[6]Lund Stem Cell Center, Department of Laboratory Medicine, Lund University, Lund, Sweden
Grainyhead-like 2 is a human homolog of Drosophila grainyhead. It inhibits epithelial-to-mesenchymal transition that is necessary for cell migration, and it is involved in neural tube closure, epithelial morphogenesis, and barrier formation during embryogenesis by regulation of the expression of cell junction proteins such as E-cadherin and vimentin. Cancer shares many common characters with development such as epithelial-to-mesenchymal transition. In addition to its important role in development, grainyhead-like 2 is implicated in carcinogenesis as well. However, the reports on grainyhead-like 2 in various cancers are controversial. Grainyhead-like 2 can act as either a tumor suppressor or an oncogene with the mechanisms not well elucidated. In this review, we summarized recent progress on grainyhead-like 2 in development and cancer in order to get an insight into the regulation network of grainyhead-like 2 and understand the roles of grainyhead-like 2 in various cancers.
基金：
Ningxia Medical University Foundation [XZ2016001]; Ningxia High Education Scientific Research Program [NGY2016120]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81472770]; Science and Technology Commision of Shanghai Changning District [CNKW 2014102]
第一作者机构：[1]Department of Oncology, Tongren Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, P.R. China
通讯作者：
通讯机构：[2]Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, P.R. China[5]Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden[6]Lund Stem Cell Center, Department of Laboratory Medicine, Lund University, Lund, Sweden[*1]Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, P.R. China.
推荐引用方式(GB/T 7714)：
Ma Lijun,Yan Hongli,Zhao Hui,et al.Grainyhead-like 2 in development and cancer[J].TUMOR BIOLOGY.2017,39(5):1-6.doi:10.1177/1010428317698375.
APA：
Ma, Lijun,Yan, Hongli,Zhao, Hui&Sun, Jianmin.(2017).Grainyhead-like 2 in development and cancer.TUMOR BIOLOGY,39,(5)
MLA：
Ma, Lijun,et al."Grainyhead-like 2 in development and cancer".TUMOR BIOLOGY 39..5(2017):1-6
