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Deficiency of CKIP-1 aggravates high-fat diet-induced fatty liver in mice

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机构: [1]Capital Med Univ, Beijing Tongren Hosp, Dept Gastroenterol, Beijing 100730, Peoples R China [2]Zhengzhou Univ, Affiliated Hosp 1, Phys Examinat Ctr, Zhengzhou 450052, Peoples R China [3]Capital Med Univ, Dept Biochem & Mol Biol, Beijing Key Lab Canc & Metastasis Res, Beijing 100069, Peoples R China [4]Capital Med Univ, Municipal Lab Liver Protect & Regulat Regenerat, Dept Cell Biol, Beijing 100069, Peoples R China [5]Beijing Inst Radiat Med, Beijing Proteome Res Ctr, State Key Lab Prote, Beijing 102206, Peoples R China
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关键词: Non-alcoholic fatty liver disease (NAFLD) Casein kinase 2 interacting protein-1 (CKIP-1) c-Jun NH2-terminal kinase 1 (JNK1) Insulin receptor substrate-1(IRS-1) High fat diet (HFD)

摘要:
Casein kinase 2 interacting protein-1(CRIF-1) is widely expressed in a variety of tissues and cells, and plays an important role in various critical cellular and physiological processes including cell growth, apoptosis, differentiation, cytoskeleton and bone formation. Here, we found: (1) CHIP-1 deficient mice exhibited increased body weight, liver weight, number and size of lipid droplets, and TG content comparing with WT mice after being exposed to high fat diet (HFD); (2) the levels of serum insulin, liver glycogen, phosphorylated C-Jun-N-terminal kinase-1 (pJNK1) and phosphorylated insulin receptor substrate -1(pIRS1) in CHIP-1(-/-) mice were higher than those of WT mice; (3) CHIP-1 interacted with JNK1 in vitro. Our results indicate that CHIP-1 deficiency in mice aggravates HFD-induced fatty liver by upregulating JNK1 phosphorylation and further upregulating IRS-1 phosphorylation and RI.

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出版当年[2016]版:
大类 | 2 区 医学
小类 | 3 区 肿瘤学 4 区 细胞生物学
最新[2023]版:
大类 | 3 区 生物学
小类 | 4 区 细胞生物学 4 区 肿瘤学
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出版当年[2015]版:
Q2 CELL BIOLOGY Q2 ONCOLOGY
最新[2023]版:
Q2 ONCOLOGY Q3 CELL BIOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

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第一作者机构: [1]Capital Med Univ, Beijing Tongren Hosp, Dept Gastroenterol, Beijing 100730, Peoples R China
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