机构：[1]Department of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China[2]Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China[3]Center for Life Sciences, National Laboratory Astana and School of Sciences and Technology, Nazarbayev University, Astana 010000, Kazakhstan[4]Department of Anesthesiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
Ether-a-go-go1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the EAG1 channels are regulated by a variety of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox-regulated ion channel family. The role of EAG1 channels in tumor development and its therapeutic significance have been well established. Meanwhile, the importance of hEAG1 channels in the nervous system is now increasingly appreciated. The present review will focus on the recent progress on the channel regulation by endogenous signals and the potential functions of EAG1 channels in normal neuronal signaling as well as neurological diseases.
基金：
National Natural Science Foundation
of China (31271217), National Basic Research Program of
China (2014CB910304), Shanghai Science and Technology
Commission (11JC1406400, 12PJ1404200), and State Key
Laboratory of Oncogenes and Related Genes Grant (90-12-
03).
第一作者机构：[1]Department of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China[2]Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
通讯作者：
推荐引用方式(GB/T 7714)：
Han Bo,Tokay Tursonjan,Zhang Guangming,et al.Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System[J].OXIDATIVE MEDICINE AND CELLULAR LONGEVITY.2017,2017:doi:10.1155/2017/7371010.
APA：
Han, Bo,Tokay, Tursonjan,Zhang, Guangming,Sun, Peng&Hou, Shangwei.(2017).Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2017,
MLA：
Han, Bo,et al."Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2017.(2017)
