机构：[1]Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Psoriatic keratinocytes express exaggerated levels of inflammatory cytokines, and show aberrant hyperproliferation and terminal differentiation in the pathogenesis of psoriasis. The antimicrobial protein hS100A7 (psoriasin) has been found highly expressed in psoriatic skin, but the mechanism and physiological function remain largely unknown. We observed that hS100A7 induces mature interleukin 1 alpha (17kDa) expression in normal human epidermal keratinocytes, which is dependent on RAGE-p38 MAPK and calpain-1 as the inhibitors or knockdown of them completely decreased the expression of mature interleukin1 alpha. Then, we proved mS100a7a15, mature IL-1 alpha and calpain-1 were highly expressed in imquimod-induced psoriasis model and mouse IL-17a-neutralizing antibody treatment attenuated mS100a7a15 expression. At last, PD 151746 (calpain-1 inhibitor) treatment decreased epidermal thickness in imquimod-induced psoriasis model. Taken together, our results suggest that mature IL-1 alpha induced by hS100A7 is via RAGE-p38 MAPK and calpain-1 pathway in keratinocyte and this mechanism may play an important role during psoriasis.
基金：
National Basic Research Program of China (973 Program)National Basic Research Program of China [2015CB910403]; National Natural Science Foundation of China (NSFC) [81570118, 81570112]
第一作者机构：[1]Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
通讯作者：
推荐引用方式(GB/T 7714)：
Lei Hu,Li Xiangyun,Jing Bo,et al.Human S100A7 Induces Mature Interleukin 1 alpha Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis[J].PLOS ONE.2017,12(1):doi:10.1371/journal.pone.0169788.
APA：
Lei, Hu,Li, Xiangyun,Jing, Bo,Xu, Hanzhang&Wu, Yingli.(2017).Human S100A7 Induces Mature Interleukin 1 alpha Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis.PLOS ONE,12,(1)
MLA：
Lei, Hu,et al."Human S100A7 Induces Mature Interleukin 1 alpha Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis".PLOS ONE 12..1(2017)
