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Tailored treatment strategies for obstructive sleep apnea.

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机构： [1]Department of Neurology, Kyung Hee University College of Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea. [2]Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada. [3]Beijing Tongren Hospital, Capital Medical University, Department of Otolaryngology Head and Neck Surgery, Beijing, China. [4]University of California at San Diego, Division of Pulmonary, Critical Care and Sleep Medicine, 9300 Campus Point Drive #7381, La Jolla, CA 92037-7381, USA.

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关键词： Sleep Apnea Lung Airway Muscle

摘要：

Obstructive sleep apnea (OSA) is characterized by repetitive collapse of the upper airway (UA) during sleep and is associated with chronic intermittent hypoxemia, catecholamine surges, and sleep disrupt. Multiple pathophysiological risk factors have been identified and contribute to OSA, including anatomical abnormalities (elevated UA mechanical load), compromised UA dilators, increased loop gain (unstable respiratory control), and decreased arousal threshold. These factors may contribute to the pathophysiology of sleep apnea in different individuals and recent evidence suggests that treatment may be targeted towards underlying pathophysiological mechanism. In some cases, combination therapy may be required to treat the condition. Copyright © 2015 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.

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最新[2023]版：

Q2 RESPIRATORY SYSTEM

影响因子： 2.4 最新[2023版] 2.4 最新五年平均 0 出版当年[2014版] 0 出版当年五年平均 0 出版前一年[2013版]

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第一作者机构： [1]Department of Neurology, Kyung Hee University College of Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea.

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