机构：[1]State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences and University of Chinese Academy of Sciences, Beijing, 100190, China[2]Beijing Tongren Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京同仁医院首都医科大学附属同仁医院
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摘要：
Glaucoma is the second leading cause of blindness and it has been the topic of massive studies to explore the underlying mechanisms of the disease. Resting-state neuroimaging studies have been widely applied to investigate the functional damage of the brain, but little is known about the alterations of the interhemispheric resting-state functional connectivity (RSFC) in patients with primary open-angle glaucoma (POAG). In the present study, we used a newly developed voxel-mirrored homotopic connectivity (VMHC) method to explore the interhemispheric RSFC of the brain in POAG patients. The result showed decreased VMHC in the precuneus and the occipital lobe including calcarine and cuneus, as well as increased VMHC in the lingual gyrus, insula, supramarginal gyrus, and frontal gyrus. Meanwhile, we found the mean VMHC in precuneus was negatively correlated (r=-0.551, P=0.041) with Cup-to-disk Ratio. Significant differences between POAG patients and normal controls reveal the altered brain regions and the functional damage, strengthening the understanding of the primary open-angle glaucoma.
基金：
NSFC (61271151, 91520202) and YICAS
语种：
外文
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第一作者机构：[1]State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences and University of Chinese Academy of Sciences, Beijing, 100190, China
推荐引用方式(GB/T 7714)：
Zhou Peng,Wang Jieqiong,Li Ting,et al.Abnormal Interhemispheric Resting-state Functional Connectivity in Primary Open-angle Glaucoma[J].2016 38TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC).2016,4055-4058.
APA：
Zhou, Peng,Wang, Jieqiong,Li, Ting,Wang, Ningli,Xian, Junfang&He, Huiguang.(2016).Abnormal Interhemispheric Resting-state Functional Connectivity in Primary Open-angle Glaucoma.2016 38TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC),,
MLA：
Zhou, Peng,et al."Abnormal Interhemispheric Resting-state Functional Connectivity in Primary Open-angle Glaucoma".2016 38TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) .(2016):4055-4058
