Background: Precise localization and excision of the originating site of a sinonasal inverted papilloma ( SNIP) is essential for decreasing tumor recurrence. In this study we evaluated the use of preoperative computed tomography (CT) and magnetic resonance imaging (MRI) to pinpoint the attachment/originating sites of SNIPs in 143 patients. Methods: Osteitis signs in CTs and convoluted cerebriform pattern (CCP)-based reverse tracings from MRIs of 143 SNIP patients were analyzed preoperatively to predict the originating site of SNIPs. The predicted sites were compared with actual SNIP attachment sites determined by surgery, and patients were followed-up for evaluation of SNIP recurrence rates over a mean period of about 4 years. Results: Osteitis signs in CT accurately predicted the actual tumor attachment site in 49.7% of all patients. In comparison, convoluted cerebriform pattern (CCP)-based reverse tracings in MRI and combination CT plus MRI accurately predicted the SNIP originating sites in 84.1% and 86% of the patients, respectively. Sensitivity and specificity in predicting the SNIP originating site were: CT, 54.6% and 69.2%; MRI, 93.1% and 76.9%; and CT+MRI, 94.6% and 92.3%, respectively. A single postoperative recurrence occurred in 4.2% of the patients. Conclusions: Preoperative combination of MRI and CT provides a better option to accurately predict the SNIP originating site, and thus may facilitate accurate and complete excision of the SNIP. (C) 2016 ARS-AAOA, LLC.
基金：
Program for Changjiang Scholars and
Innovative Research Team (IRT13082 to L.Z.); National Science Fund for the
Major International Joint Research Program (81420108009 to L.Z.); The 12th
Five Year Science and Technology Support Program (2014BAI07B04 to L.Z.
and C.W.); Beijing Municipal Administration of Hospitals Clinical Medicine
Development of Special Funding Support (ZYLX201310 to L.Z.); Natural
Science Foundation of China (81400444 to H.L., 81470678 to C.W.); Beijing
Natural Science Foundation (7131006 to L.Z.); Beijing Health Bureau
Program for High Level Talents (2011-3-043 to C.W.); Beijing Municipal
Administration of Hospitals’ Mission Plan (SML20150203 to L.Z.); Beijing
Sinonasal inverted papilloma (SNIP) is one of the most
common forms of benign sinonasal tumors, demonstrating a high recurrence rate of 15%–25.3% after
surgery.1–3 SNIPs sometimes present with a malignant tendency, which coexists with squamous cell carcinoma in approximately 6.5% to 10% patients.1, 3, 4 Thus, it is essential to achieve complete surgical resection, especially at the
original location where the SNIP adheres to the bone wall.
Computed tomography (CT) has often been used to study
the original location of SNIP, and the osteitis sign and
neo-osteogenesis have been shown to be reliable markers for the site of attachment of the SNIP.5 However,
Municipal Administration of Hospitals’ Youth Programme (QML20150202 to
H.L.).
第一作者机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China[2]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China[3]Capital Med Univ, Beijing DiTan Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China[2]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China[*1]Beijing Inst Otolaryngol, 17 Hou Gou Hu Tong, Beijing 100005, Peoples R China
推荐引用方式(GB/T 7714)：
Fang Gaoli,Lou Hongfei,Yu Wenling,et al.Prediction of the originating site of sinonasal inverted papilloma by preoperative magnetic resonance imaging and computed tomography[J].INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY.2016,6(12):1221-1228.doi:10.1002/alr.21836.
APA：
Fang, Gaoli,Lou, Hongfei,Yu, Wenling,Wang, Xiangdong,Yang, Bentao...&Zhang, Luo.(2016).Prediction of the originating site of sinonasal inverted papilloma by preoperative magnetic resonance imaging and computed tomography.INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY,6,(12)
MLA：
Fang, Gaoli,et al."Prediction of the originating site of sinonasal inverted papilloma by preoperative magnetic resonance imaging and computed tomography".INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY 6..12(2016):1221-1228
