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miR-760 mediates chemoresistance through inhibition of epithelial mesenchymal transition in reast cancer cells

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收录情况： ◇ SCIE

作者：
Hu, S-H[1] * ; Wang, C-H[2] ; Huang, Z-J[3] ; Liu, F.[4] ; Xu, C-W[5] ; Li, X-L[5] ; Chen, G-Q[6] ;
机构： [1]Dali Univ, Affiliated Hosp, Dept Clin Lab, Dali, Peoples R China [2]Shanghai Putuo Dist Liqun Hosp, Dept Med Oncol, Shanghai, Peoples R China [3]Fujian Med Univ, Affiliated Hosp, Fujian Prov Canc Hosp, Dept Breast Surg, Fuzhou, Peoples R China [4]Fujian Med Univ, Affiliated Hosp, Fujian Prov Canc Hosp, Dept Pathol, Fuzhou, Peoples R China [5]Capital Med Univ, Grad Sch, Beijing, Peoples R China [6]Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Gen Surg, Shanghai, Peoples R China
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关键词： Breast cancer Drug resistance mIR-760 Epitheli-al-mesenchymal transition

摘要：
OBJECTIVE: Therapeutic resistance has been a great obstacle for successful treatment of breast cancer. Our study aimed to explore the role of microRNA-760 (miR-760) in chemoresistant breast cancer cells. MATERIALS AND METHODS: Real-time PCR was performed to measure the mRNA expression of miR-760 and Nanog. Western blot was used to determine the protein expression of Nanog and mesenchymal and epithelial markers. Cell viability was measured by the CCK-8 assay. RESULTS: Our results showed that the expression of miR-760 was significantly reduced the doxorubicin (DOX)-resistant MCF-7/DOX cells and chemoresistant breast cancer tissues. Moreover, up-regulation of miR-760 sensitized breast cancer cells to the anti-cancer agents. The MCF7/DOX cells exhibited increased expression of Snail, a mesenchymal marker, and decreased levels of E-Cadherin, an epithelial marker. In addition, overexpression of miR-760 suppressed the expression of Nanog, a transcriptional factor involved in chemoresistance, and resulted in the reversal of EMT in breast cancer cells. CONCLUSIONS: Our study demonstrated that miR-760 modulated chemoresistance through the epithelial-mesenchymal transition in breast cancer cells, providing a potential therapeutic target for treatment of drug-resistant breast cancer.

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出版当年[2015]版：
大类 | 4 区 医学
小类 | 4 区 药学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 药学
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出版当年[2014]版：
Q4 PHARMACOLOGY & PHARMACY
最新[2023]版：
无

影响因子： 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

第一作者：
第一作者机构： [1]Dali Univ, Affiliated Hosp, Dept Clin Lab, Dali, Peoples R China
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推荐引用方式(GB/T 7714)：
Hu S-H,Wang C-H,Huang Z-J,et al.miR-760 mediates chemoresistance through inhibition of epithelial mesenchymal transition in reast cancer cells[J].EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES.2016,20(23):5002-5008.
APA：
Hu, S-H,Wang, C-H,Huang, Z-J,Liu, F.,Xu, C-W...&Chen, G-Q.(2016).miR-760 mediates chemoresistance through inhibition of epithelial mesenchymal transition in reast cancer cells.EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES,20,(23)
MLA：
Hu, S-H,et al."miR-760 mediates chemoresistance through inhibition of epithelial mesenchymal transition in reast cancer cells".EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 20..23(2016):5002-5008

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