机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science KeyLaboratory, Capital Medical University, Beijing, China,首都医科大学附属北京同仁医院临床科室眼科眼底科[2]Department of Neurology, Beijing TianTan Hospital,Capital Medical University, Beijing, China,首都医科大学附属天坛医院[3]Channing Laboratory, Department of Medicine, Brigham andWomen’s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America,[4]Department of Nutritional Sciences, The Pennsylvania State University, Department of NutritionalSciences, University Park, Pennsylvania, United States of America,[5]Beijing Institute of Ophthalmology,Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, CapitalMedical University, Beijing, China,研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[6]Department of Cardiology, Kailuan Hospital, Hebei United University,Tangshan, China,[7]Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht- KarlsUniversity, Mannheim, Germany
Purpose To assess relationships between carotid artery atherosclerosis and retinal arteriolar and venular diameters. Methods The community-based longitudinal Asymptomatic Polyvascular Abnormalities Community Study (APAC) included a sub-population of the Kailuan study which consisted of 101,510 employees and retirees of a coal mining industry. Based on the Chinese National Census 2010 and excluding individuals with history of cerebrovascular ischemic events, 4004 individuals were included into the APAC. All participants underwent a detailed clinical examination including blood laboratory tests and carotid artery duplex ultrasound examination. The cerebrospinal fluid pressure (CSFP) was estimated using the formula: CSFP[mmHg] = 0.44xBody Mass Index[kg/m(2)]+ 0.16xDiastolic Blood Pressure[mmHg]-0.18 x Age[Years]-1.91. Results In multivariable analysis (goodness of fit r(2) : 0.12), thicker retinal arteries were associated with a thinner common carotid artery intima-media thickness (IMT) (P = 0.002; standardized regression coefficient beta:-0.06; non-standardized regression coefficient B:-6.92; 95% confidence interval (CI):-11.2,-2.61) after adjusting for thicker retinal nerve fiber layer (P< 0.001; beta: 0.18; B: 0.35; 95% CI: 0.28,0.42), lower diastolic blood pressure (P<0.001; beta:-0.16; B:-0.17; 95% CI:-0.21,-0.3), younger age (P<0.001; beta:-0.08; B:-0.16; 95%; CI:-0.25,-0.08), and less abdominal circumference (P = 0.003; beta:-0.06; B:-0.11; 95% CI:-0.18,-0.03). Thicker retinal vein diameter was associated (r = 0.40) with higher estimated CSFP (P<0.001; beta: 0.09; B: 0.78; 95% CI: 0.47,1.08) after adjusting for wider retinal arteries (P<0.001; beta: 0.27; B: 0.36; 95% CI: 0.31,0.41), thicker retinal nerve fiber layer thickness (P = 0.03; beta: 0.22; B: 0.56; 95% CI: 0.46,0.65) and male gender (P<0.001; beta:-0.08; B:-3.98; 95% CI:-5.88,2.09). Conclusions Thinner retinal artery diameter was significantly, however weakly, associated with increased common carotid artery IMT. It suggests that retinal microvascular changes were only week indicators for an atherosclerotic carotid artery pathology. Thicker retinal vein diameter was associated with higher estimated CSFP, confirming associations between higher estimated CSFP and higher incidence of retinal vein occlusion.
基金：
Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20150201]; Science & Technology Project of Beijing Municipal Science & Technology Commission [Z151100001615052]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81570891, 81272981]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201307]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7151003]; Advanced Health Care Professionals Development Project of Beijing Municipal Health Bureau [2014-2-003]
第一作者机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science KeyLaboratory, Capital Medical University, Beijing, China,
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Jing Yan,Yang Xuan,Li Yang,et al.Carotid Atherosclerosis, Cerebrospinal Fluid Pressure, and Retinal Vessel Diameters: The Asymptomatic Polyvascular Abnormalities in Community Study[J].PLOS ONE.2016,11(12):doi:10.1371/journal.pone.0166993.
APA：
Yang, Jing Yan,Yang, Xuan,Li, Yang,Xu, Jie,Zhou, Yong...&Jonas, Jost B..(2016).Carotid Atherosclerosis, Cerebrospinal Fluid Pressure, and Retinal Vessel Diameters: The Asymptomatic Polyvascular Abnormalities in Community Study.PLOS ONE,11,(12)
MLA：
Yang, Jing Yan,et al."Carotid Atherosclerosis, Cerebrospinal Fluid Pressure, and Retinal Vessel Diameters: The Asymptomatic Polyvascular Abnormalities in Community Study".PLOS ONE 11..12(2016)
