Background/Aims: Since the middle ear cavity plays an important role in middle ear effusion, the goal of this study is to examine the morphological and functional development of the middle ear mucosa in neonatal and adult gerbils. Methods: Gerbils aged between postnatal day 1 (P1) and P26 were used for the experiments. The morphological development of the middle ear cavity was measured by using the celloidin embedding method and scanning electronic microscope. Ciliary motion was determined and calibrated by a photodiode-based measurement system. Results: The area of the middle ear increased significantly from 0.42 +/- 0.02 mm(2) (n = 8) at P1 to 2.6 +/- 0.03 mm(2) (n = 8) at P26. At P1, all regions were covered by densely populated ciliated cells. A significant reduction of the density of ciliated cells was found between P8 and P18 (p < 0.05). The beat frequency at P1 is not statistically different from that of P8 (p > 0.05). However, the beat frequency increased significantly between P8 and P18 (p < 0.05). Conclusion: Middle ear mucosa underwent a significant change between P1 and P18. The cilia morphology and function (ciliary motion) are fully mature at P18. This may explain the high incidence of middle ear effusion in the neonatal period in humans. (C) 2016 S. Karger AG, Basel
基金：
Discipline Leader Training Program of Health and Family Planning Commission, Qingpu District, Shanghai, PR China [WD2015-04]
第一作者机构：[1]Fudan Univ, Hosp Zhongshan Qingpu, Dept Otorhinolaryngol, Shanghai, Peoples R China[2]Creighton Univ, Sch Med, Dept Biomed Sci, Omaha, NE USA
通讯作者：
通讯机构：[4]Fudan Univ, Zhongshan Hosp, Dept Otorhinolaryngol, 180 Fenglin Rd, Shanghai 200032, Peoples R China[5]Beijing Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, 1 Dongjiaomin Lane, Beijing 100730, Peoples R China[*1]Department of Otorhinolaryngology Zhongshan Hospital, Fudan University 180 Fenglin Road, Shanghai 200032 (PR China)[*2]Department of Otorhinolaryngology – Head and Neck Surgery Beijing Tongren Hospital, Beijing Capital Medical University 1 Dongjiaomin Lane, Dongcheng District Beijing 100730 (PR China)
推荐引用方式(GB/T 7714)：
Li Jun,Liu Huizhan,He Nancy T.,et al.Morphology and Ciliary Motion of the Middle Ear Mucosa of Neonatal and Adult Gerbils[J].ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY.2016,78(5):296-301.doi:10.1159/000452338.
APA：
Li, Jun,Liu, Huizhan,He, Nancy T.,Shen, Na&Li, Yi.(2016).Morphology and Ciliary Motion of the Middle Ear Mucosa of Neonatal and Adult Gerbils.ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY,78,(5)
MLA：
Li, Jun,et al."Morphology and Ciliary Motion of the Middle Ear Mucosa of Neonatal and Adult Gerbils".ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY 78..5(2016):296-301
