机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China首都医科大学附属同仁医院[3]College of Biomedical Engineering, Capital Medical University, Beijing, China[4]Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[5]Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Seegartenklinik Heidelberg, Germany
Purpose To evaluate changes in subfoveal choroidal thickness (SFCT) and peripapillary choroidal thickness (PPCT) after acute intraocular pressure (IOP) elevation provoked by a dark room prone provocative test (DRPPT). Methods The prospective cohort study included 114 eyes from 65 individuals who had an IOP elevation >= 2 mu m Hg during the DRPPT. The participants stayed in a dark room for 2 h with the forehead placed on a desk. At baseline and within 5 min after the end of the DRPPT, tonometry and enhanced depth imaging by spectral- domain optical coherence tomography were carried out. Results During the DRPPT, IOP increased by 10.1 +/- 10.9 mu m Hg, SFCT decreased significantly (p<0.001) from 280 +/- 80 mu m to 267 +/- 76 mu m and PPCT decreased significantly (p<0.001) from 177 +/- 74 to 169 +/- 70 mu m. In multivariate analysis, a more marked SFCT thinning was associated with higher IOP increase (p<0.001) and shallower anterior chamber depth at baseline (p=0.01). In a similar manner, a higher PPCT change was correlated with a higher IOP increase (p<0.001), and a thicker choroidal thickness at baseline (p<0.001). Conclusions Choroidal thickness in the subfoveal region and in the peripapillary region decreased parallel to an acute increase in IOP in individuals 2 h after a dark room test. Choroidal thickness depends on the actual IOP, which may be noted when choroidal thickness is measured.
基金：
(National Natural Science Foundation of
China) grant number (81570835).
第一作者机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University[2]Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China[*1]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chong Wen Men, Beijing 100005, China
通讯作者：
通讯机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University[2]Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China[5]Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Seegartenklinik Heidelberg, Germany[*1]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chong Wen Men, Beijing 100005, China
推荐引用方式(GB/T 7714)：
Wang Ya Xing,Jiang Ran,Ren Xiao Lei,et al.Intraocular pressure elevation and choroidal thinning[J].BRITISH JOURNAL OF OPHTHALMOLOGY.2016,100(12):1676-1681.doi:10.1136/bjophthalmol-2015-308062.
APA：
Wang, Ya Xing,Jiang, Ran,Ren, Xiao Lei,Chen, Jian Dong,Shi, Hong Li...&Jonas, Jost B..(2016).Intraocular pressure elevation and choroidal thinning.BRITISH JOURNAL OF OPHTHALMOLOGY,100,(12)
MLA：
Wang, Ya Xing,et al."Intraocular pressure elevation and choroidal thinning".BRITISH JOURNAL OF OPHTHALMOLOGY 100..12(2016):1676-1681
医学