Purpose: Using optical coherence tomographic angiography (OCT-angiography), we examined the vasculature of the choriocapillaris in patients with central serous chorioretinopathy (CSC). Methods: The prospective observational clinical study included patients with CSC defined by painless loss of central visual acuity and presence of a serous macular detachment as visualized by spectral-domain OCT. All eyes underwent OCT-angiography. Subfoveal choroidal thickness and choriocapillaris width were measured. Results: The study included 26 eyes of 21 patients with a mean age of 47.0 +/- 7.9 years (range: 34-65 years). All 26 eyes showed an image pattern of high signal intensity, and 21 eyes additionally demonstrated dilated capillaries in the OCT-angio images. The areas showing abnormalities in the OCT-angiography were congruent with leaking areas in fluorescein angiography or areas with hyperpermeability in indocyanine green angiography. Among 16 patients with unilateral CSC, 1 patient showed a high intensity pattern in the OCT-angiogram in the contralateral, clinically unaffected eye. Parallel to thicker choroidal thickness measurements in affected eyes as compared with contralateral unaffected eyes in unilateral CSC, OCT-angiography revealed significantly thicker choriocapillaris measurements in the affected eyes. Conventional fluorescein angiography did not demonstrate leakage in 14 of 18 eyes with clinically diagnosed CSC. Conclusion: Optical coherence tomographic angiography showed an image pattern of high signal intensity in all eyes with CSC and dilated vessels in the choriocapillaris in most eyes with clinically diagnosed CSC. The results indicate that OCT-angiography may become a noninvasive valuable tool for the diagnosis of CSC in particular and for the diagnosis of macular disorders in general.
基金:
Beijing Municipal Administration of Hospitals
Clinical Medicine Development of Special Funding Support (code:
ZYLX201307); the National Natural Science Foundation of China
(No. 81272981); the Beijing Natural Science Foundation (No.
7151003); and the Advanced Health Care Professionals Development Project of Beijing Municipal Health Bureau (No. 2014-2-003).
第一作者机构:[1]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Ophthalmol & Visual Sci Key Lab, 1 Dong Jiao Min Xiang, Beijing 100730, Peoples R China
通讯作者:
通讯机构:[1]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Ophthalmol & Visual Sci Key Lab, 1 Dong Jiao Min Xiang, Beijing 100730, Peoples R China[*1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Laboratory, Capital Medical University, 1 Dong Jiao Min Xiang, Dong Cheng District, Beijing 100730, China
推荐引用方式(GB/T 7714):
Chan Szy Yann,Wang Qian,Wei Wen Bin,et al.OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY IN CENTRAL SEROUS CHORIORETINOPATHY[J].RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES.2016,36(11):2051-2058.doi:10.1097/IAE.0000000000001064.
APA:
Chan, Szy Yann,Wang, Qian,Wei, Wen Bin&Jonas, Jost B..(2016).OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY IN CENTRAL SEROUS CHORIORETINOPATHY.RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,36,(11)
MLA:
Chan, Szy Yann,et al."OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY IN CENTRAL SEROUS CHORIORETINOPATHY".RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 36..11(2016):2051-2058