PURPOSE: To measure the density of the superficial retinal small vessel network (SRSVN), superficial retinal capillary network (SRCN), deep retinal capillary network (DRCN), and choriocapillaris and the size of the foveal avascular zone (FAZ) in the superficial retinal layer in normal eyes. DESIGN: Prospective observational cross-sectional study. METHODS: In healthy Chinese volunteers, the retinal and choroidal vasculature was visualized by split spectrum amplitude decorrelation angiography-associated optical coherence tomography (RTVueXR Avanti device; Optovue Inc, Fremont, California, USA). RESULTS: Among 105 healthy participants (age: 35.9 +/- 13.8 years) mean FAZ measured 0.35 +/- 0.12 mm(2), and mean density of SRSVN, SRCN, DRCN, and choriocapillaris was 8.54% +/- 0.92%, 31.8% +/- 2.6%, 45.8% +/- 3.3%, 44.4% +/- 3.3%, and 44.5% +/- 2.7%, respectively. In multivariate analysis, higher SRSVN density was associated with younger age (P = .001; standardized regression coefficient beta: -0.28), male sex (P = .008; 11: -0.23), lower SRCN density (P < .001; beta: -0.40), and larger mean choriocapillaris vessel diameter (P = .001; beta: 0.30). Higher SRCN density was correlated with male sex (P = .007; beta: -0.19), lower SRSVN density (P < .001; beta: -0.44), and higher density of the radial peripapillary capillary density (P = .004; beta: 0.20). Higher DRCN density was correlated with younger age (P < .001; beta: -0.31), female sex (P = .002; beta: 0.22), higher SRCN density (P < .001; beta: 0.38), and higher choriocapillaris density (P < .001; beta: 0.39). Higher choriocapillaris network density in the central region was associated with higher DRCN density (P < .001; beta: 0.43) and lower radial peripapillary capillary density (P = .005; beta: -0.26). All retinal vascular parameters were not significantly correlated with axial length or subfoveal choroidal thickness. CONCLUSIONS: The density of the macular vascular networks decreases with older age and is independent of axial length and subfoveal choroidal thickness in healthy individuals. (C) 2016 Elsevier Inc. All rights reserved.
基金：
BEIJING MUNICIPAL ADMINISTRATION OF HOSPITALS CLINICAL MEDICINE DEVELOPment of Special Funding Support (Beijing) [ZYLX201307]; National Natural Science Foundation of China (Beijing)National Natural Science Foundation of China (NSFC) [81272981]; Beijing Natural Science Foundation (Beijing)Beijing Natural Science Foundation [7151003]; Advanced Health Care Professionals Development Project of Beijing Municipal Health Bureau (Beijing) [2014-2-003]
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Beijing Ophthalmol & Visual Sci Key Lab, Beijing Tongren Eye Ctr, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Hosp, Beijing Ophthalmol & Visual Sci Key Lab, Beijing Tongren Eye Ctr, Beijing, Peoples R China[*1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Wang Qian,Chan Szyyann,Yang Jing Yan,et al.Vascular Density in Retina and Choriocapillaris as Measured by Optical Coherence Tomography Angiography[J].AMERICAN JOURNAL OF OPHTHALMOLOGY.2016,168:95-109.doi:10.1016/j.ajo.2016.05.005.
APA：
Wang, Qian,Chan, Szyyann,Yang, Jing Yan,You, Bing,Wang, Ya Xing...&Bin Wei, Wen.(2016).Vascular Density in Retina and Choriocapillaris as Measured by Optical Coherence Tomography Angiography.AMERICAN JOURNAL OF OPHTHALMOLOGY,168,
MLA：
Wang, Qian,et al."Vascular Density in Retina and Choriocapillaris as Measured by Optical Coherence Tomography Angiography".AMERICAN JOURNAL OF OPHTHALMOLOGY 168.(2016):95-109
医学