机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Otolaryngology, Head and Neck Surgery, General Hospital of Ningxia Medical University, Yinchuan, PR China[3]Division of Pulmonary and Critical Care Medicine La Jolla, University of California at San Diego, Sandiego, CA, USA[4]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China医技科室放射科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[5]Department of Otolaryngology, Head and Neck Surgery, Beijing Tsinghua Chang Gung Hospital, Beijing, PR China[6]Department of Otolaryngology, Head and Neck Surgery, Peking University First Hospital, Beijing, PR China
Conclusion: Variability of GGEMG at sleep onset is associated with apnea severity in OSA patients. At sleep onset, a lower decline in GGEMG might suggest a more severe OSA. Objective: The goal of this study was to evaluate genioglossus (GG) activation in the Chinese population at early sleep onset, and clarify the relationship of GG activation and the apnea severity in patients with Obstructive Sleep Apnea (OSA). Methods: Thirty-five OSA patients and 10 normal controls underwent overnight polysomnography with synchronous genioglossus electromyography (GGEMG) using intra-oral electrodes. The upper airway (UA) anatomy was evaluated by three-dimensional computer tomography (3D-CT) in all subjects. Results: The average GGEMG and tonic GGEMG were higher in the apnea patients than in the normal controls during wakefulness and early sleep onset period (three breaths) (p<0.01). Eight OSA patients had increased GGEMG at sleep onset and 27 patients had decreased GGEMG values. Between the two groups, there were significant differences in the apnea-hypopnea index (AHI), minimal cross-sectional airway area (mCAS) and minimal lateral airway dimension (mLAT) at velopharynx (p<0.05). The change in GGEMG, phasic GGEMG and tonic GGEMG from awake to sleep showed positive correlations with AHI and negative correlations with velopharynx (mLAT and mCAS) (p<0.05).
基金：
National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81170902, 81200735]; National Science and Technology Support Plan [2013BAI03B05]
第一作者机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China[2]Department of Otolaryngology, Head and Neck Surgery, General Hospital of Ningxia Medical University, Yinchuan, PR China
通讯作者：
通讯机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China[5]Department of Otolaryngology, Head and Neck Surgery, Beijing Tsinghua Chang Gung Hospital, Beijing, PR China[*1]Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Chongnei Street 2, Beijing 100730, PR China[*2]Department of Otolaryngology, Head and Neck Surgery, Beijing Tsinghua Chang Gung Hospital, Tiantongyuan Area, Changping District, Beijing 100044, PR China
推荐引用方式(GB/T 7714)：
Zhao Di,Li Yanru,Xian Junfang,et al.Relationship of genioglossus muscle activation and severity of obstructive sleep apnea and hypopnea syndrome among Chinese patients[J].ACTA OTO-LARYNGOLOGICA.2016,136(8):819-825.doi:10.3109/00016489.2016.1163418.
APA：
Zhao, Di,Li, Yanru,Xian, Junfang,Qu, Yue,Zhang, Junbo...&Ye, Jingying.(2016).Relationship of genioglossus muscle activation and severity of obstructive sleep apnea and hypopnea syndrome among Chinese patients.ACTA OTO-LARYNGOLOGICA,136,(8)
MLA：
Zhao, Di,et al."Relationship of genioglossus muscle activation and severity of obstructive sleep apnea and hypopnea syndrome among Chinese patients".ACTA OTO-LARYNGOLOGICA 136..8(2016):819-825
