This study aimed to investigate the clinical effects of different surgical interventions in treating post-cesarean intractable postpartum hemorrhage (pC-IPH). The clinical data of 75 pC-IPH cases were retrospectively analyzed, and the hemostatic measures were divided into the uterine packing group (group A, 33 cases), improved uterine strapping group (group B, 25 cases), and uterine artery embolization group (group C, 17 cases). The blood loss, operative time, hemostasis success rate, and hysterectomy rate were compared among the groups. The blood loss and operative time of group C were less than groups A and B (258/723, 556, 48/67, 71, P < 0.05); the hemostasis success rate and hysterectomy rate of groups C, A, and B were 88.2/78.8, 72.0, P > 0.05, and 11.8/12.1, 16.0, P > 0.05, respectively. The hemostasis success rate in patients with placental factors was higher in group C than in groups A and B (100/33.3, 0.0, P < 0.05). Surgical intervention had good hemostatic effect for IPH, and arterial embolization had the advantages of less bleeding, shorter operative time, and better hemostatic effect; high risk of failed hemostasis was due to placental factors and coagulation disorders.