机构:[1]Capital Med Univ, Beijing Tongren Hosp, Dept Emergency, Beijing, Peoples R China首都医科大学附属北京同仁医院临床科室急诊科[2]Capital Med Univ, Beijing Tongren Hosp, Comprehens Med Dept, Beijing, Peoples R China首都医科大学附属北京同仁医院首都医科大学附属同仁医院
This study aimed to explore correlations between haplotypes of the angiotensin II receptor type 1 (AGTR1) gene and coronary heart disease (CHD). In total, 204 patients with CHD and 206 healthy controls were genotyped using denaturing high-performance liquid chromatography between 2008 and 2014. Five polymorphic loci were found, namely, A-43281G, A-32954G, G-32839A, G-11064A, and A1880G. Likelihood estimates were used to identify haplotypes consisting of the A1166C locus and four of these five loci, then correlations between these haplotypes and CHD were assessed. Eight haplotypes with a frequency greater than 3% in the study population were discerned: ACCAA [ odds ratio (OR) = 1.2381, 95% confidence interval (CI) = 0.7726-1.9843]; ACCCA (OR = 1.2604, 95% CI = 0.6104-2.6027); ACTAA (OR = 0.8929, 95% CI = 0.6607-1.2067); ACTAG (OR = 0.9274, 95% CI = 0.5692-1.5110); ATTAA (OR = 1.0347, 95% CI = 0.7505-1.4265); ATTAG (OR = 0.9110, 95% CI = 0.4227-1.9631); GCCAA (OR = 1.1273, 95% CI = 0.7259-1.7506); and GCTAA (OR = 0.7981, 95% CI = 0.4379-1.4546). However, the frequency of these haplotypes did not significantly differ between CHD and the control groups. Thus, no correlation was established between the occurrence of CHD and AGTR1 haplotypes present at frequencies greater than 3%.
第一作者机构:[1]Capital Med Univ, Beijing Tongren Hosp, Dept Emergency, Beijing, Peoples R China
通讯作者:
推荐引用方式(GB/T 7714):
Duan L. J.,Wang X. D..Analysis of correlations between coronary heart disease and haplotypes of the angiotensin II receptor type 1 (AGTR1) gene[J].GENETICS AND MOLECULAR RESEARCH.2016,15(1):doi:10.4238/gmr.15017457.
APA:
Duan, L. J.&Wang, X. D..(2016).Analysis of correlations between coronary heart disease and haplotypes of the angiotensin II receptor type 1 (AGTR1) gene.GENETICS AND MOLECULAR RESEARCH,15,(1)
MLA:
Duan, L. J.,et al."Analysis of correlations between coronary heart disease and haplotypes of the angiotensin II receptor type 1 (AGTR1) gene".GENETICS AND MOLECULAR RESEARCH 15..1(2016)