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Analysis of correlations between coronary heart disease and haplotypes of the angiotensin II receptor type 1 (AGTR1) gene

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机构: [1]Capital Med Univ, Beijing Tongren Hosp, Dept Emergency, Beijing, Peoples R China [2]Capital Med Univ, Beijing Tongren Hosp, Comprehens Med Dept, Beijing, Peoples R China
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关键词: AGTR1 Gene polymorphism Coronary atherosclerotic heart disease

摘要:
This study aimed to explore correlations between haplotypes of the angiotensin II receptor type 1 (AGTR1) gene and coronary heart disease (CHD). In total, 204 patients with CHD and 206 healthy controls were genotyped using denaturing high-performance liquid chromatography between 2008 and 2014. Five polymorphic loci were found, namely, A-43281G, A-32954G, G-32839A, G-11064A, and A1880G. Likelihood estimates were used to identify haplotypes consisting of the A1166C locus and four of these five loci, then correlations between these haplotypes and CHD were assessed. Eight haplotypes with a frequency greater than 3% in the study population were discerned: ACCAA [ odds ratio (OR) = 1.2381, 95% confidence interval (CI) = 0.7726-1.9843]; ACCCA (OR = 1.2604, 95% CI = 0.6104-2.6027); ACTAA (OR = 0.8929, 95% CI = 0.6607-1.2067); ACTAG (OR = 0.9274, 95% CI = 0.5692-1.5110); ATTAA (OR = 1.0347, 95% CI = 0.7505-1.4265); ATTAG (OR = 0.9110, 95% CI = 0.4227-1.9631); GCCAA (OR = 1.1273, 95% CI = 0.7259-1.7506); and GCTAA (OR = 0.7981, 95% CI = 0.4379-1.4546). However, the frequency of these haplotypes did not significantly differ between CHD and the control groups. Thus, no correlation was established between the occurrence of CHD and AGTR1 haplotypes present at frequencies greater than 3%.

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出版当年[2015]版:
大类 | 4 区 生物
小类 | 4 区 生化与分子生物学 4 区 遗传学
最新[2025]版:
大类 | 4 区 生物学
小类 | 4 区 遗传学
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出版当年[2014]版:
Q4 GENETICS & HEREDITY Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版:
Q4 GENETICS & HEREDITY

影响因子: 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

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第一作者机构: [1]Capital Med Univ, Beijing Tongren Hosp, Dept Emergency, Beijing, Peoples R China
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