机构：[1]Department of Biology, Nazarbayev University School of Science and Technology, Astana 010000, Republic of Kazakhstan.[2]Institute of International Medical Research, Department of Urology and Andrology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, P.R. China.[3]Department of Pathology, Sun Yat-sen University, Guangzhou 510080, P.R. China.[4]Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana 010000, Republic of Kazakhstan.[5]Department of Urology, Tong Ji Hospital, Tong Ji University, Shanghai 200065, P.R. China.
Proviral integration site for Moloney murine leukemia virus-1 (Pim-1) is a serine/threonine kinase that regulates multiple cellular functions such as cell cycle, cell survival, drug resistance. Aberrant elevation of Pim-1 kinase is associated with numerous types of cancer. Two distinct isoforms of Pim-1 (Pim-1S and Pim-1L) show distinct cellular functions. Pim-1S predominately localizes to the nucleus and Pim-1L localizes to plasma membrane for drug resistance. Recent studies show that mitochondrial Pim-1 maintains mitochondrial integrity. Pim-1 is emerging as a cancer drug target, particularly in prostate cancer. Recently the potent new functions of Pim-1 in immunotherapy, senescence bypass, metastasis and epigenetic dynamics have been found. The aim of the present updated review is to provide brief information regarding networks of Pim-1 kinase and focus on its recent advances as a novel drug target.
第一作者机构：[1]Department of Biology, Nazarbayev University School of Science and Technology, Astana 010000, Republic of Kazakhstan.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Biology, Nazarbayev University School of Science and Technology, Astana 010000, Republic of Kazakhstan.[*1]Department of Biology, Nazarbayev University School of Science and Technology, Astana 010000, Republic of Kazakhstan
推荐引用方式(GB/T 7714)：
Tursynbay Yernar,Zhang Jinfu,Li Zhi,et al.Pim-1 kinase as cancer drug target: An update.[J].BIOMEDICAL REPORTS.2016,4(2):140-146.doi:10.3892/br.2015.561.
APA：
Tursynbay Yernar,Zhang Jinfu,Li Zhi,Tokay Tursonjan,Zhumadilov Zhaxybay...&Xie Yingqiu.(2016).Pim-1 kinase as cancer drug target: An update..BIOMEDICAL REPORTS,4,(2)
MLA：
Tursynbay Yernar,et al."Pim-1 kinase as cancer drug target: An update.".BIOMEDICAL REPORTS 4..2(2016):140-146
