机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]INSERM, U968, 75012 Paris, France[3]UPMC Universite Paris 06, UMR ´ S 968, Institut de la Vision, 75012 Paris, France[4]CNRS, UMR 7210, 75012 Paris, France[5]Quinze-Vingts National Ophthalmology Hospital, 75012 Paris, France[6]Versailles Saint-Quentin-en-Yvelines University, 78000 Versailles, France
Purpose. To evaluate the relationship between corneal and conjunctival epithelium thickness and ocular surface clinical tests in dry eye disease (DED) patients. Patients and Methods. Fifty-four patients with DED and 32 control subjects were included. Each patient underwent an ocular surface evaluation using the ocular surface disease index (OSDI), tear film break-up time (TBUT), corneal and conjunctival staining, tear film lipid layer analysis, and Schirmer test. The central corneal (CET), limbal (LET), and bulbar conjunctival epithelium thickness (BET) were acquired using spectral-domain optical coherence tomography (SD-OCT). Results. Compared to control subjects, mean BET was significantly thicker and mean LET was significantly lower in the DED group. There was no significant difference in mean CET between the two groups. The mean LET was correlated with OSDI and TBUT. The inferior LET was correlated with OSDI, Schirmer I test, TBUT, Oxford score, and corneal sensitivity. Mean BET was correlated with OSDI and TBUT, but not with Schirmer I test and Oxford score. Conclusions. In dry eye patients, a thinner limbal epithelium and a thicker bulbar conjunctival epithelium were observed. These changes were correlated to the severity of dry eye symptoms and tear film alterations.
基金：
Central Health Research Project Fund, China [W2013BJ47]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区眼科学
最新[2023]版：
大类|4 区医学
小类|4 区眼科学
JCR分区：
出版当年[2014]版：
Q3OPHTHALMOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China
通讯作者：
推荐引用方式(GB/T 7714)：
Liang Qingfeng,Liang Hong,Liu Hanruo,et al.Ocular Surface Epithelial Thickness Evaluation in Dry Eye Patients: Clinical Correlations[J].JOURNAL OF OPHTHALMOLOGY.2016,2016:doi:10.1155/2016/1628469.
APA：
Liang, Qingfeng,Liang, Hong,Liu, Hanruo,Pan, Zhiqiang,Baudouin, Christophe&Labbe, Antoine.(2016).Ocular Surface Epithelial Thickness Evaluation in Dry Eye Patients: Clinical Correlations.JOURNAL OF OPHTHALMOLOGY,2016,
MLA：
Liang, Qingfeng,et al."Ocular Surface Epithelial Thickness Evaluation in Dry Eye Patients: Clinical Correlations".JOURNAL OF OPHTHALMOLOGY 2016.(2016)
