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Genetic polymorphisms and HPV infection in oral squamous cell carcinomas

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机构: [1]Qingdao Univ, Yuhuangding Hosp, Dept Otorhinolaryngol & Head & Neck Surg, Yantai, Peoples R China [2]Capital Med Univ, Dept Otolaryngol Head & Neck Surg, Key Lab Otolaryngol Head & Neck Surg,Minist Educ, Beijing Tongren Hosp,Beijing Inst Otolaryngol, Beijing 100730, Peoples R China [3]Qingdao Univ, Yuhuangding Hosp, Dept Ophthalmol, Yantai 264000, Peoples R China [4]Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77030 USA [5]Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA
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Despite declining smoking rates in the United States, the incidence of oral squamous cell carcinomas (OSCC, including oral cavity and oropharynx) is rising in young adults. The reasons have been attributed to changes in sexual behaviors and the increasingly prevalent infection of oncogenic subtypes of human papillomavirus (HPV), principally type16 and occasionally type18. However, only small proportion of individuals who have contracted HPV infection will develop OSCC, suggesting that there is an inter-individual variation in susceptibility to HPV infection and related OSCC. Identification of susceptible biomarkers for HPV status would be useful to identify those individuals who are susceptible to HPV infection, to refine the prognostication of HPV associated OSCC, and ultimately to improve prevention efforts for OSCC and potentially other HPV-associated diseases. Our public health OSCC prevention paradigm will need to expand beyond tobacco and alcohol control.

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基金编号: P30CA016672

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出版当年[2014]版:
大类 | 2 区 医学
小类 | 2 区 病毒学
最新[2023]版
大类 | 2 区 医学
小类 | 2 区 病毒学
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出版当年[2013]版:
Q1 VIROLOGY
最新[2023]版:
Q1 VIROLOGY

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第一作者机构: [1]Qingdao Univ, Yuhuangding Hosp, Dept Otorhinolaryngol & Head & Neck Surg, Yantai, Peoples R China
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通讯机构: [4]Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77030 USA [5]Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA
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