Despite declining smoking rates in the United States, the incidence of oral squamous cell carcinomas (OSCC, including oral cavity and oropharynx) is rising in young adults. The reasons have been attributed to changes in sexual behaviors and the increasingly prevalent infection of oncogenic subtypes of human papillomavirus (HPV), principally type16 and occasionally type18. However, only small proportion of individuals who have contracted HPV infection will develop OSCC, suggesting that there is an inter-individual variation in susceptibility to HPV infection and related OSCC. Identification of susceptible biomarkers for HPV status would be useful to identify those individuals who are susceptible to HPV infection, to refine the prognostication of HPV associated OSCC, and ultimately to improve prevention efforts for OSCC and potentially other HPV-associated diseases. Our public health OSCC prevention paradigm will need to expand beyond tobacco and alcohol control.
基金:
NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P30CA016672] Funding Source: NIH RePORTER
第一作者机构:[1]Qingdao Univ, Yuhuangding Hosp, Dept Otorhinolaryngol & Head & Neck Surg, Yantai, Peoples R China
共同第一作者:
通讯作者:
通讯机构:[4]Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77030 USA[5]Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA
推荐引用方式(GB/T 7714):
Sun Yan,Zhang Yang,Liu Limei,et al.Genetic polymorphisms and HPV infection in oral squamous cell carcinomas[J].CURRENT OPINION IN VIROLOGY.2015,14:1-6.doi:10.1016/j.coviro.2015.05.004.
APA:
Sun, Yan,Zhang, Yang,Liu, Limei,Song, Xicheng&Li, Guojun.(2015).Genetic polymorphisms and HPV infection in oral squamous cell carcinomas.CURRENT OPINION IN VIROLOGY,14,
MLA:
Sun, Yan,et al."Genetic polymorphisms and HPV infection in oral squamous cell carcinomas".CURRENT OPINION IN VIROLOGY 14.(2015):1-6