Highly Active Antiretroviral Therapy (HAART)-Related Hypertriglyceridemia Is Associated With Failure of Recovery of CD14lowCD16+ Monocyte Subsets in AIDS Patients
As cellular reservoirs, CD16(+) monocyte subsets play important roles in the progression of HIV infection. Previous studies have shown that highly active antiretroviral therapy (HAART) reduced the percentages of CD14(high)CD16(+) monocyte subsets, but did not recover the percentages of CD14(low)CD16(+) subsets. Eighty-four chronic HIV-infected, HAART-naive individuals and 55 HIV-negative subjects (31 without hyperlipidemia and 24 with hypertriglyceridemia) were enrolled. Plasma HIV-1 RNA levels, CD4(+) T-cell counts, triglycerides, total cholesterol, high-density lipoprotein, and low-density lipoprotein were followed up for 48 weeks during HAART treatment in the longitudinal study. We found that mild hypertriglyceridemia in HIV-negative subjects and HIV-infected patients, naive to HAART, did not affect the percentage of monocyte subsets. However, a failure of CD14(low)CD16(+) subset recovery was observed in patients with HAART-related hypertriglyceridemia at 48 weeks. Thus, HAART-related hypertriglyceridemia altered homeostasis of monocyte subsets to antiviral therapy, which might further affect immune reconstitution.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81371804]; Capital Health Research and Development of Special [2014-2-2173]
第一作者机构：[1]Capital Med Univ, Beijing Ditan Hosp, Inst Infect Dis, Beijing 100730, Peoples R China[2]Capital Med Univ, Beijing Ditan Hosp, Beijing Key Lab Emerging Infect Dis, Beijing 100730, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Ditan Hosp, Inst Infect Dis, Beijing 100730, Peoples R China[2]Capital Med Univ, Beijing Ditan Hosp, Beijing Key Lab Emerging Infect Dis, Beijing 100730, Peoples R China[7]Capital Med Univ, Beijing Tongren Hosp, Dept Geriatr Med, Beijing 100730, Peoples R China[*1]Department of Geriatric Medicine, Beijing Tongren Hospital, Capital Medical University, No. 2, Chongwenmennei Street, Dongcheng District, Beijing 100730, China[*2]Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Jingshundongjie 8, Chaoyang District, Beijing 100015, China
推荐引用方式(GB/T 7714)：
Han Junyan,Zhao Hongxin,Ma Yaluan,et al.Highly Active Antiretroviral Therapy (HAART)-Related Hypertriglyceridemia Is Associated With Failure of Recovery of CD14lowCD16+ Monocyte Subsets in AIDS Patients[J].MEDICINE.2015,94(27):doi:10.1097/MD.0000000000001115.
APA：
Han, Junyan,Zhao, Hongxin,Ma, Yaluan,Zhou, Haiwei,Hao, Yu...&Qin, Mingzhao.(2015).Highly Active Antiretroviral Therapy (HAART)-Related Hypertriglyceridemia Is Associated With Failure of Recovery of CD14lowCD16+ Monocyte Subsets in AIDS Patients.MEDICINE,94,(27)
MLA：
Han, Junyan,et al."Highly Active Antiretroviral Therapy (HAART)-Related Hypertriglyceridemia Is Associated With Failure of Recovery of CD14lowCD16+ Monocyte Subsets in AIDS Patients".MEDICINE 94..27(2015)
