The purpose of this study was to determine the timing of acid-induced increase in saliva secretion and to investigate the possibility of parasympathetic reinnervation of transplanted submandibular glands (SMGs). Citric acid stimulation-induced changes in secretion of transplanted SMGs were evaluated in 27 patients who underwent SMG transplantation for keratoconjunctivitis sicca (KCS); Tc-99m scintigraphy and Schirmer tests were done at 1, 3, 6, and 9 months after transplantation. Acetylcholinesterase staining was conducted to confirm the presence of parasympathetic reinnervation in three SMGs at 6 and 9 months after transplantation. Schirmer tests showed significantly increased secretion of the transplanted SMGs after acid stimulation at 6 and 9 months, but not at 1 and 3 months. On Tc-99m scintigraphy, no decline was detected on the dynamic time-activity curve after acid stimulation at 1 and 3 months, but a decline was detected in nine glands at 6 months and in 19 glands at 9 months. No decline was observed in the remaining eight glands at 9 months after transplantation. The histology findings were consistent with scintigraphy results. In conclusion, acid-induced increase in saliva secretion occurs at >= 6 months after SMG transplantation, and parasympathetic reinnervation of the transplanted SMG might occur.
基金：
National Natural Science
Foundation of China (Nos. 81070847
and 81271161), Ministry of Education
(No. 20120001110045), the Beijing Natural Science Foundation (No. 7132201),
and Peking University School of Stomatology (PKUSS20110102).
第一作者机构：[1]Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
通讯作者：
通讯机构：[1]Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China[*1]Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology Beijing 100081 China
推荐引用方式(GB/T 7714)：
Liu X. J.,Li M.,Su J. Z.,et al.The timing of acid-induced increase in saliva secretion in transplanted submandibular glands[J].INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY.2015,44(8):1041-1047.doi:10.1016/j.ijom.2015.01.003.
APA：
Liu, X. J.,Li, M.,Su, J. Z.,Xie, Z.&Yu, G. Y..(2015).The timing of acid-induced increase in saliva secretion in transplanted submandibular glands.INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,44,(8)
MLA：
Liu, X. J.,et al."The timing of acid-induced increase in saliva secretion in transplanted submandibular glands".INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 44..8(2015):1041-1047
