Interleukin-25 (IL-25) and IL-33, which belong to distinct cytokine families, induce and promote T helper type 2 airway inflammation. Both cytokines probably play a role in asthma, but there is a lack of direct evidence to clarify distinctions between their functions and how they might contribute to distinct 'endotypes' of disease. To address this, we made a direct comparison of the effects of IL-25 and IL-33 on airway inflammation and physiology in our established murine asthma surrogate, which involves per-nasal, direct airway challenge. Intranasal challenge with IL-33 or IL-25 induced inflammatory cellular infiltration, collagen deposition, airway smooth muscle hypertrophy, angiogenesis and airway hyperresponsiveness, but neither increased systemic production of IgE or IgG1. Compared with that of IL-25, the IL-33-induced response was characterized by more sustained laying down of extracellular matrix protein, neoangiogenesis, T helper type 2 cytokine expression and elevation of tissue damping. Hence, both IL-25 and IL-33 may contribute significantly and independently to asthma 'endotypes' when considering molecular targets for the treatment of human disease.
基金:
National Natural Science Foundation of China
(81102250, 81270153, 81373177, 81471594), the Science
and Technology Project of the Beijing Municipal Education Commission (KM201110025005), PhD Programs
Foundation of Ministry of Education of China
(20101107110003), Capital Health Development of Scientific Research (Shou-Fa: 2011-1004-01), Key Projects in
the National Science & Technology Pillar Program during
the Twelfth Five-year Plan Period (2012BAI05B01,2012-
BAI05B02) and the Program of Beijing Municipality
Health System for High-Level Talent (2011-2-04).
第一作者机构:[1]Capital Med Univ, Beijing Chao Yang Hosp, Dept Resp & Crit Care Med, Beijing 100020, Peoples R China[2]Beijing Inst Resp Med, Beijing 100020, Peoples R China
通讯作者:
通讯机构:[1]Capital Med Univ, Beijing Chao Yang Hosp, Dept Resp & Crit Care Med, Beijing 100020, Peoples R China[2]Beijing Inst Resp Med, Beijing 100020, Peoples R China[3]Capital Med Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100069, Peoples R China[6]Kings Coll London, Div Asthma Allergy & Lung Biol, MRC & Asthma UK Ctr Allerg Mech Asthma, London WC2R 2LS, England[*1]Capital Med Univ, Beijing Chao Yang Hosp, Dept Resp & Crit Care Med, 8 Gong Ti Nan Lu, Beijing 100020, Peoples R China[*2]The Department of Immunology, School of Basic Medical Sciences, Capital Medical University, 10# Xi Tou Tiao, You An Men Wai, Fengtai District, Beijing 100069, China
推荐引用方式(GB/T 7714):
Li Yan,Wang Wei,Huang Ping,et al.Distinct sustained structural and functional effects of interleukin-33 and interleukin-25 on the airways in a murine asthma surrogate[J].IMMUNOLOGY.2015,145(4):508-518.doi:10.1111/imm.12465.
APA:
Li, Yan,Wang, Wei,Huang, Ping,Zhang, Qian,Yao, Xiujuan...&Ying, Sun.(2015).Distinct sustained structural and functional effects of interleukin-33 and interleukin-25 on the airways in a murine asthma surrogate.IMMUNOLOGY,145,(4)
MLA:
Li, Yan,et al."Distinct sustained structural and functional effects of interleukin-33 and interleukin-25 on the airways in a murine asthma surrogate".IMMUNOLOGY 145..4(2015):508-518