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Distinct sustained structural and functional effects of interleukin-33 and interleukin-25 on the airways in a murine asthma surrogate

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机构: [1]Capital Med Univ, Beijing Chao Yang Hosp, Dept Resp & Crit Care Med, Beijing 100020, Peoples R China [2]Beijing Inst Resp Med, Beijing 100020, Peoples R China [3]Capital Med Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100069, Peoples R China [4]Capital Med Univ, Beijing Tongren Hosp, Dept Resp Med, Beijing, Peoples R China [5]Capital Med Univ, Dept Lab Anim Sci, Beijing, Peoples R China [6]Kings Coll London, Div Asthma Allergy & Lung Biol, MRC & Asthma UK Ctr Allerg Mech Asthma, London WC2R 2LS, England
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关键词: asthma interleukin-25 interleukin-33 remodelling

摘要:
Interleukin-25 (IL-25) and IL-33, which belong to distinct cytokine families, induce and promote T helper type 2 airway inflammation. Both cytokines probably play a role in asthma, but there is a lack of direct evidence to clarify distinctions between their functions and how they might contribute to distinct 'endotypes' of disease. To address this, we made a direct comparison of the effects of IL-25 and IL-33 on airway inflammation and physiology in our established murine asthma surrogate, which involves per-nasal, direct airway challenge. Intranasal challenge with IL-33 or IL-25 induced inflammatory cellular infiltration, collagen deposition, airway smooth muscle hypertrophy, angiogenesis and airway hyperresponsiveness, but neither increased systemic production of IgE or IgG1. Compared with that of IL-25, the IL-33-induced response was characterized by more sustained laying down of extracellular matrix protein, neoangiogenesis, T helper type 2 cytokine expression and elevation of tissue damping. Hence, both IL-25 and IL-33 may contribute significantly and independently to asthma 'endotypes' when considering molecular targets for the treatment of human disease.

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出版当年[2014]版:
大类 | 2 区 医学
小类 | 3 区 免疫学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 免疫学
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出版当年[2013]版:
Q2 IMMUNOLOGY
最新[2023]版:
Q2 IMMUNOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

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第一作者机构: [1]Capital Med Univ, Beijing Chao Yang Hosp, Dept Resp & Crit Care Med, Beijing 100020, Peoples R China [2]Beijing Inst Resp Med, Beijing 100020, Peoples R China
通讯作者:
通讯机构: [1]Capital Med Univ, Beijing Chao Yang Hosp, Dept Resp & Crit Care Med, Beijing 100020, Peoples R China [2]Beijing Inst Resp Med, Beijing 100020, Peoples R China [3]Capital Med Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100069, Peoples R China [6]Kings Coll London, Div Asthma Allergy & Lung Biol, MRC & Asthma UK Ctr Allerg Mech Asthma, London WC2R 2LS, England [*1]Capital Med Univ, Beijing Chao Yang Hosp, Dept Resp & Crit Care Med, 8 Gong Ti Nan Lu, Beijing 100020, Peoples R China [*2]The Department of Immunology, School of Basic Medical Sciences, Capital Medical University, 10# Xi Tou Tiao, You An Men Wai, Fengtai District, Beijing 100069, China
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