Objective: This paper reports the outcome of using acellular dermal matrix to repair a cervical skin defect in a patient with an advanced laryngeal carcinoma that had invaded the skin. Case report: A 55-year-old man underwent surgical repair of severe atypical hyperplasia and of a squamous cell carcinoma at 17 and 9 months, respectively, prior to undergoing the current procedure. Five months prior to the current procedure, his left cervical skin broke down and the lesion gradually enlarged. A pathological diagnosis of squamous cell carcinoma was made. The cervical skin defect was repaired with a tailored acellular dermal matrix patch. The cervical wound completely healed without developing infection or a pharyngeal fistula, and the patient exhibited no dysphagia three years after surgery. Conclusion: Cervical skin defects can be successfully repaired with acellular dermal matrix.