We assessed the possible correlation between genetic polymorphisms in interleukin (IL)-1 beta, IL-8, and IL-10 and risk of acute pancreatitis. Polymorphisms of IL-1 beta +3954C/T (rs1143634), IL-1 beta -511C/T (rs16944), IL-8 -251T/A (rs4073), IL-10 -1082A/G (rs1800896), and IL-10 -819C/T (rs1800871) were assessed by polymerase chain reaction-restriction fragment length polymorphism. Patients with acute pancreatitis were more likely to have a family history of acute pancreatitis and a habit of tobacco smoking and alcohol drinking. Conditional logistic regression analyses showed that subjects carrying IL-10 -1082A/G and IL-8 -251 AA genotype with the A allele were significantly associated with an increased risk of acute pancreatitis, with adjusted odds ratio (95% confidence interval) of 1.82 (1.01-3.31) and 1.39 (1.02-1.90), respectively. However, we did not observe that IL-1 beta +3954C/T, IL-1 beta -511C/T, IL-10 -1082A/G, and IL-10 -819C/T polymorphisms were associated with the risk of acute pancreatitis. We found that the IL-8 -251T/A polymorphism is associated with an increased risk of acute pancreatitis, and no significant association between IL-1 beta and IL-10 gene polymorphisms and risk of acute pancreatitis was detected.
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Emergency, Beijing, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Li D.,Li J.,Wang L.,et al.Association between IL-1β, IL-8, and IL-10 polymorphisms and risk of acute pancreatitis[J].GENETICS AND MOLECULAR RESEARCH.2015,14(2):6635-6641.doi:10.4238/2015.June.18.6.
APA：
Li, D.,Li, J.,Wang, L.&Zhang, Q..(2015).Association between IL-1β, IL-8, and IL-10 polymorphisms and risk of acute pancreatitis.GENETICS AND MOLECULAR RESEARCH,14,(2)
MLA：
Li, D.,et al."Association between IL-1β, IL-8, and IL-10 polymorphisms and risk of acute pancreatitis".GENETICS AND MOLECULAR RESEARCH 14..2(2015):6635-6641
