机构：[1]Key Laboratory of Yangtze River Water Environment, College of Environmental Science and Engineering, Tongji University, Ministry of Education, Shanghai 200092, China[2]Department of Stomatology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China[3]Division of Cardiology, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, 1111 Xianxia Road, Shanghai 200336, China
Microcystins (MCs) produced by toxic cyanobacteria cause serious water pollution and public health hazard to humans and animals. However, direct molecular mechanisms of MC-LR in vascular endothelial cells (ECs) have not been understood yet. In this study, we investigated whether MC-LR induces vascular inflammatory process in cultured human umbilical vein endothelial cells (HUVECs). Our data demonstrated that MC-LR decreased HUVECs proliferation and tube formation and enhanced apoptosis. MC-LR also induced intracellular reactive oxygen species formation (ROS) in HUVECs. The MC-LR directly stimulated phosphorylation of NF-kappa B. Furthermore, MC-LR also increased cell adhesion molecules (ICAM-1 and VCAM-1) expression in HUVECs. Taken together, the present data suggested that MC-LR induced vascular inflammatory process, which may be closely related to the oxidative stress, NF-kappa B activation, and cell adhesion molecules expression in HUVECs. Our findings may highlight that MC-LR causes potential damage to blood vessels.
基金：
Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [81401870, 81400927]; Shanghai Municipal Science and Technology CommissionScience & Technology Commission of Shanghai Municipality (STCSM) [13ZR1459000, 13ZR1414600]; Shanghai Municipal Science and Technology Commission Guidance Project [134119a3600]
第一作者机构：[1]Key Laboratory of Yangtze River Water Environment, College of Environmental Science and Engineering, Tongji University, Ministry of Education, Shanghai 200092, China
通讯作者：
推荐引用方式(GB/T 7714)：
Shi Jun,Zhou Jie,Zhang Min.Microcystins Induces Vascular Inflammation in Human Umbilical Vein Endothelial Cells via Activation of NF-kappa B[J].MEDIATORS OF INFLAMMATION.2015,2015:doi:10.1155/2015/942159.
APA：
Shi, Jun,Zhou, Jie&Zhang, Min.(2015).Microcystins Induces Vascular Inflammation in Human Umbilical Vein Endothelial Cells via Activation of NF-kappa B.MEDIATORS OF INFLAMMATION,2015,
MLA：
Shi, Jun,et al."Microcystins Induces Vascular Inflammation in Human Umbilical Vein Endothelial Cells via Activation of NF-kappa B".MEDIATORS OF INFLAMMATION 2015.(2015)
