NSCL/P is a common congenital defect and gene-environmental factors involve in this disorder. Periconceptional intake of folate may reduce the risk of NSCL/P. The present study investigated three SNPs (rs1801198, rs955516, and rs3733890) in three folate pathway genes, including TCN2, MTR, and BHMT among 481 patients and 558 healthy subjects. Rs955516 showed allelic association with NSCL/P. More patients carry rs955516 AA and rs3733890 AA genotypes. The gene-gene interaction test showed trans-phase combination effects for MTR and BHMT genes. Our study suggests that the interaction of MTR and BHMT genes play a vital role in the pathogenesis of NSCL/P in Chinese population.
基金：
This work was supported by the National Natural Science Foundation of China (Grant number 30700997), Beijing
Natural Science Foundation (Grant number 7082038) and a Grant for High-level Talents of Beijing Health System (Grant
number 2013-3-036).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区环境科学与生态学
小类|4 区环境科学4 区公共卫生、环境卫生与职业卫生
最新[2025]版：
大类|4 区医学
小类|4 区环境科学4 区公共卫生、环境卫生与职业卫生
JCR分区：
出版当年[2013]版：
Q3ENVIRONMENTAL SCIENCESQ3PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
最新[2023]版：
Q2ENVIRONMENTAL SCIENCESQ2PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
第一作者机构：[1]Capital Med Univ, Sch Stomatol, Beijing Stomatol Hosp, Inst Dent Res, Beijing 100050, Peoples R China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Jin Ling Ling,Chen Er Jun,Hou Wei,et al.The Association between Folate Pathway Genes and Cleft Lip With or Without Cleft Palate in a Chinese Population[J].BIOMEDICAL AND ENVIRONMENTAL SCIENCES.2015,28(2):136-139.doi:10.3967/bes2015.016.
APA：
Jin Ling Ling,Chen Er Jun,Hou Wei,Liu Xin Hua&Hu Ying.(2015).The Association between Folate Pathway Genes and Cleft Lip With or Without Cleft Palate in a Chinese Population.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,28,(2)
MLA：
Jin Ling Ling,et al."The Association between Folate Pathway Genes and Cleft Lip With or Without Cleft Palate in a Chinese Population".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 28..2(2015):136-139
