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Integrated transcriptome analysis reveals miRNA-mRNA crosstalk in laryngeal squamous cell carcinoma

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收录情况： ◇ SCIE

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机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing 100005, China [2]National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [3]Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China

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关键词： Laryngeal squamous cell carcinoma Gene expression Small RNAs Data integration

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Next generation sequencing (NGS) has proven to be a powerful tool in delineating myriads of molecular subtypes of cancer, as well as in revealing accumulation of genomic mutations throughout cancer progression. Whole genome microRNA (miRNA) and mRNA expression profiles were obtained from patients with laryngeal squamous cell carcinoma (LSCC) using deep sequencing technology, and were analyzed by utilizing integrative computational approaches. A large number of protein-coding and non-coding genes were detected to be differentially expressed, indicating a functional switch in LSCC cells. A total of 127 mutated genes were detected to be significantly associated with ectoderm and epidermis development. Eleven miRNAs were found to be differentially expressed, including a potential cancer suppressor miRNA, mir-34c, which was dramatically down-regulated. Integrated analysis of mRNA and miRNA transcriptomes further revealed correlated dynamics among 11 miRNAs and 138 targeted genes, forming a highly dynamical co-regulation network response to LSCC development. (C) 2014 Elsevier Inc. All rights reserved.

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出版当年[2013]版：

大类 | 3 区生物

小类 | 3 区生物工程与应用微生物 3 区遗传学

最新[2025]版：

大类 | 2 区生物学

小类 | 2 区生物工程与应用微生物 3 区遗传学

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出版当年[2012]版：

Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 GENETICS & HEREDITY

最新[2023]版：

Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 GENETICS & HEREDITY

影响因子： 3.4 最新[2023版] 3.5 最新五年平均 3.01 出版当年[2012版] 2.998 出版当年五年平均 3.019 出版前一年[2011版] 2.793 出版后一年[2013版]

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第一作者机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing 100005, China

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