Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 x 10(-8) for rs6445055), two on chromosome 9 (P = 2.80 x 10(-11) for rs2472493 near ABCA1 and P = 6.39 x 10(-11) for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 x 10(-11) for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG.
基金:
MRCUK Research & Innovation (UKRI)Medical Research Council UK (MRC) [MC_PC_U127561128] Funding Source: UKRI; National Institute for Health ResearchNational Institute for Health Research (NIHR) [SRF/01/010] Funding Source: researchfish; Fight for Sight [1895/96, 1329/30] Funding Source: researchfish; NATIONAL EYE INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Eye Institute (NEI) [R01EY022124, R01EY023512, K08EY022943, R01EY022305, P30EY014104, R01EY015473] Funding Source: NIH RePORTER; NATIONAL HUMAN GENOME RESEARCH INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Human Genome Research Institute (NHGRI) [ZIAHG200327, U01HG004728] Funding Source: NIH RePORTER; Department of HealthEuropean Commission [SRF/01/010] Funding Source: Medline; Medical Research CouncilUK Research & Innovation (UKRI)Medical Research Council UK (MRC)European Commission [MC_PC_U127561128] Funding Source: Medline; NEI NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Eye Institute (NEI) [R01 EY022305, P30 EY014104, R01 EY023512, R01 EY015473, R01 EY022124, K08 EY022943] Funding Source: Medline; NHGRI NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Human Genome Research Institute (NHGRI) [U01 HG004728] Funding Source: Medline; Chief Scientist Office [CZB/4/438, CZB/4/710] Funding Source: Medline
Hysi Pirro G.,Cheng Ching-Yu,Springelkamp Henriet,et al.Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma[J].NATURE GENETICS.2014,46(10):1126-1130.doi:10.1038/ng.3087.
APA:
Hysi, Pirro G.,Cheng, Ching-Yu,Springelkamp, Henriet,Macgregor, Stuart,Bailey, Jessica N. Cooke...&Aung, Tin.(2014).Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.NATURE GENETICS,46,(10)
MLA:
Hysi, Pirro G.,et al."Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma".NATURE GENETICS 46..10(2014):1126-1130