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The Handan Eye Study: Comparison of Screening Methods for Primary Angle Closure Suspects in a Rural Chinese Population

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机构: [1]Capital Med Univ, Beijing TongRen Hosp, Beijing TongRen Eye Ctr, Beijing Ophthalmol & Visual Sci Key Lab, Beijing 100730, Peoples R China [2]Beijing Inst Ophthalmol, Beijing, Peoples R China [3]Nanjing Aier Eye Hosp, Nanjing, Jiangsu, Peoples R China [4]Queensland Eye Inst, Brisbane, Qld, Australia [5]Univ Queensland, Brisbane, Qld, Australia
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关键词: Anterior segment OCT case detection pentacam primary angle closure suspect scanning peripheral anterior chamber depth analyzer screening van herick test

摘要:
Objective: To evaluate the van Herick test, anterior segment optical coherence tomography (AS-OCT), Pentacam and scanning peripheral anterior chamber depth analyzer (SPAC) for detecting primary angle-closure suspect (PACS) in a rural Chinese population. Methods: Eligible subjects aged >= 40 years were examined at the 5-year follow-up of the Handan Eye Study. PACS was defined as non-visibility of the posterior pigmented trabecular meshwork for >= 180 degrees of the angle. Sensitivity, specificity, predictive values and receiver operating characteristic curves were used to assess the tests. Results: A total of 425 right eyes of 431 eligible subjects were analyzed. The area under the curve (AUC) for the van Herick test and AS-OCT were 0.711 and 0.799, respectively. The AUC for Pentacam anterior chamber depth was 0.834, while anterior chamber angle and anterior chamber volume had AUCs of 0.680 and 0.800, respectively. The AUC for SPAC was 0.779. AS-OCT had a specificity of 87% with a sensitivity of 73%. The best specificity of 92% (sensitivity 19%) was achieved by the van Herrick test at the 15% cut-off. Conclusions: None of the tests evaluated achieved the combination of specificity and sensitivity needed for population-based screening and their current capability does not realize the objective of case detection in the setting of an ophthalmology clinic.

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出版当年[2013]版:
大类 | 4 区 医学
小类 | 3 区 眼科学
最新[2023]版:
大类 | 4 区 医学
小类 | 3 区 眼科学
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出版当年[2012]版:
Q2 OPHTHALMOLOGY
最新[2023]版:
Q3 OPHTHALMOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2012版] 出版当年五年平均 出版前一年[2011版] 出版后一年[2013版]

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第一作者机构: [1]Capital Med Univ, Beijing TongRen Hosp, Beijing TongRen Eye Ctr, Beijing Ophthalmol & Visual Sci Key Lab, Beijing 100730, Peoples R China
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通讯机构: [1]Capital Med Univ, Beijing TongRen Hosp, Beijing TongRen Eye Ctr, Beijing Ophthalmol & Visual Sci Key Lab, Beijing 100730, Peoples R China [2]Beijing Inst Ophthalmol, Beijing, Peoples R China [*1]Capital Med Univ, Beijing TongRen Hosp, Beijing TongRen Eye Ctr, Beijing Ophthalmol & Visual Sci Key Lab, 1 Dong Jiao Min Xiang St, Beijing 100730, Peoples R China
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