机构：[1]Department of pathology, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Beijing 100730, China医技科室病理科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Pathology, Qinghai Provincial People’s Hospital, 2 Gonghe Road, Xining, Qinghai 810007, China[3]Department of Pathology, The Affiliated Xiangya Hospital of Xiangya School Medical School, Central South University, Changsha 410013, China[4]Department of Surgery, SUNY Upstate Medical University, 750 E. Adams Street, Syracuse, NY 13210, USA[5]Department of Anesthesiology, Hunan Provincial Tumor Hospital, The Affiliated Tumor Hospital of Xiangya School Medical School of Central South University, 283 Tongzipo Road, Changsha, Hunan 410013, China
In this study, we first generated and characterized a polyclonal antibody against unique domain of matrlin-2 and then used this specific antibody to assess the expression pattern of matrilin-2 by immunohistochemistry. We found that marilin-2 is widely distributed in the connective tissues of many mouse tissues including heart, colon, penis, esophagus, lung, kidney, tracheal cartilage, developmental bone, and adult bone. The expression level of matrilin-2 was remarkably increased in the tissues of osteoarthritis developmental articular cartilage, compared to normal healthy tissues. Furthermore, we determined matrilin-2 expression in specific epithelial cells in stomach and ductal epithelial cells of salivary gland. In other tissues, the positive signals were mainly located around cardiac muscle cells and Purkinje fibers in the heart; corpus spongiosum in the penis; submucosa in the colon and esophagus; extracellular matrix of cartilage in the tracheal cartilage; and, glomerulus, the basement membrane of distal convoluted tubule and renal matrix in kidney. These observations indicated that the distribution pattern of matrilin-2 is heterogeneous in each tissue. Matrilin-2 may play an important role in the communication of matrix to matrix and matrix to cells and will be used as a potential biomarker in the early stage of osteoarthritis of articular cartilage.
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最新[2023]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Department of pathology, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Beijing 100730, China[2]Department of Pathology, Qinghai Provincial People’s Hospital, 2 Gonghe Road, Xining, Qinghai 810007, China
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推荐引用方式(GB/T 7714)：
Zhang Shukun,Peng Jinwu,Guo Yan,et al.Matrilin-2 Is a Widely Distributed Extracellular Matrix Protein and a Potential Biomarker in the Early Stage of Osteoarthritis in Articular Cartilage[J].BIOMED RESEARCH INTERNATIONAL.2014,2014:doi:10.1155/2014/986127.
APA：
Zhang, Shukun,Peng, Jinwu,Guo, Yan,Javidiparsijani, Sara,Wang, Guirong...&Luo, Junming.(2014).Matrilin-2 Is a Widely Distributed Extracellular Matrix Protein and a Potential Biomarker in the Early Stage of Osteoarthritis in Articular Cartilage.BIOMED RESEARCH INTERNATIONAL,2014,
MLA：
Zhang, Shukun,et al."Matrilin-2 Is a Widely Distributed Extracellular Matrix Protein and a Potential Biomarker in the Early Stage of Osteoarthritis in Articular Cartilage".BIOMED RESEARCH INTERNATIONAL 2014.(2014)
