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Diabetic retinopathy: Neuron protection as a therapeutic target

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收录情况： ◇ SCIE

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机构： [1]Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital [2]Beijing Ophthalmology & Visual Sciences Key Lab, Capital Medical University, 100730 PR China [3]Manhattan Eye, Ear & Throat Hospital, 210 East 64th Street, New York, NY, 10021 USA [4]Discipline of Pathology, The University of Sydney, NSW 2006, Australia [5]Macular Research Group, Save Sight Institute, Department of Clinical Ophthalmology, University of Sydney, NSW 2000, Australia

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关键词： Diabetic Retinopathy Microvasculopathy Neuropathy Treatment Apoptosis

摘要：

Diabetic retinopathy (DR) has mainly been regarded as a microvascular disease that is caused by hyperglycaemia and characterized by retinal vascular leakage, macular oedema and preretinal neovascularisation. Increasing clinical evidence from electroretinographic, contrast sensitivity, perimetric, and colour vision studies suggest that neuronal changes may occur prior to clinically detectable microvasculopathy. Thus, there may be a primary neurodegenerative process which contributes to loss of vision in DR. Neuronal apoptosis in DR has been reported both in vivo and in vitro. Consequently, neuroprotection in DR may be a valuable therapeutic target. This review outlines the recent new concepts of neurodegeneration in the pathogenesis of DR, particularly emphasising its potential for new therapeutic approaches. (C) 2013 Elsevier Ltd. All rights reserved.

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出版当年[2012]版：

大类 | 2 区生物

小类 | 3 区生化与分子生物学 3 区细胞生物学

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学 3 区细胞生物学

JCR分区：

出版当年[2011]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CELL BIOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

影响因子： 3.4 最新[2023版] 4.3 最新五年平均 4.634 出版当年[2011版] 4.759 出版当年五年平均 4.956 出版前一年[2010版] 4.152 出版后一年[2012版]

第一作者：

第一作者机构： [1]Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital [2]Beijing Ophthalmology & Visual Sciences Key Lab, Capital Medical University, 100730 PR China [5]Macular Research Group, Save Sight Institute, Department of Clinical Ophthalmology, University of Sydney, NSW 2000, Australia [*1]Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University PR China

通讯作者：

通讯机构： [1]Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital [2]Beijing Ophthalmology & Visual Sciences Key Lab, Capital Medical University, 100730 PR China [5]Macular Research Group, Save Sight Institute, Department of Clinical Ophthalmology, University of Sydney, NSW 2000, Australia [*1]Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University PR China

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