机构：[1]Beijing Tongren Eye Center, Medical Sciences College of Capital University, Beijing, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Ophthalmic Laboratories and Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[3]Shenzhen Eye Hospital, Jinan University, Shenzhen, China[4]West China MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[5]Department of Ophthalmology, Universit¨atsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
PURPOSE. We examined changes of the central nervous system in patients with advanced primary open-angle glaucoma (POAG). METHODS. The clinical observational study included 15 patients with bilateral advanced POAG and 15 healthy normal control subjects, matched for age and sex with the study group. Retinal nerve fiber layer (RNFL) thickness was measured by optical coherence tomography (OCT). Using a 3-dimensional magnetization-prepared rapid gradient-echo sequence (3D-MP-RAGE) of magnetic resonance imaging (MRI) and optimized voxel-based morphometry (VBM), we measured the cross-sectional area of the optic nerve and optic chiasm, and the gray matter volume of the brain. RESULTS. Patients in the POAG group compared to the subjects in the control group showed a significant (P < 0.001) decrease in the bilateral gray-matter volume in the lingual gyrus, calcarine gyrus, postcentral gyrus, superior frontal gyrus, inferior frontal gyrus, and rolandic operculum, as well as in the right cuneus, right inferior occipital gyrus, left paracentral lobule, and right supramarginal gyrus. Patients in the study group showed a significant increase in the bilateral gray matter volume in the middle temporal gyrus, inferior parietal gyrus, and angular gyrus, and in the left gray matter volume in the superior parietal gyrus, precuneus, and middle occipital gyrus. In addition, the cross-sectional area of the optic nerve and optic chiasm, and RNFL thickness were significantly decreased in the POAG group. CONCLUSIONS. In patients with POAG, three-dimensional MRI revealed widespread abnormalities in the central nervous system beyond the visual cortex. (Invest Ophthalmol Vis Sci. 2013;54:545-554) DOI:10.1167/iovs.12-9893
基金：
National Natural Science FoundationNational Natural Science Foundation of China [81030027, 81227002, 81220108013]; National Key Technologies R&D Program of ChinaNational Key Technology R&D Program [2012BAI01B03]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2012M520329]
第一作者机构：[1]Beijing Tongren Eye Center, Medical Sciences College of Capital University, Beijing, China[2]Ophthalmic Laboratories and Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China
共同第一作者：
通讯作者：
通讯机构：[3]Shenzhen Eye Hospital, Jinan University, Shenzhen, China[*1]Shenzhen Eye Hospital, Jinan University, Shenzhen, 518040, P. R. China
推荐引用方式(GB/T 7714)：
Chen Wei W.,Wang Ningli,Cai Suping,et al.Structural Brain Abnormalities in Patients with Primary Open-Angle Glaucoma: A Study with 3T MR Imaging[J].INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.2013,54(1):545-554.doi:10.1167/iovs.12-9893.
APA：
Chen, Wei W.,Wang, Ningli,Cai, Suping,Fang, Zhijia,Yu, Man...&Gong, Qiyong.(2013).Structural Brain Abnormalities in Patients with Primary Open-Angle Glaucoma: A Study with 3T MR Imaging.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,54,(1)
MLA：
Chen, Wei W.,et al."Structural Brain Abnormalities in Patients with Primary Open-Angle Glaucoma: A Study with 3T MR Imaging".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54..1(2013):545-554
医学