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Suprachoroidal injection of ketorolac tromethamine does not cause retinal damage

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收录情况: ◇ SCIE ◇ CSCD-C

机构: [1]Ningxia Med Univ, Gen Hosp, Yinchuan 750004, Ningxia Hui Aut, Peoples R China [2]Capital Med Univ, Beijing Tongren Eye Ctr, Beijing Tongren Hosp, Beijing 100730, Peoples R China [3]Beijing Ophthalmol & Visual Sci Key Lab, Beijing 100730, Peoples R China
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关键词: nonsteroidal anti-inflammatory drug ketorolac tromethamine segment disease retina suprachoroidal space retinal toxicity electroretinography pharmacology regeneration neural regeneration

摘要:
Rabbit right eyes were injected with 3 or 6 mg ketorolac tromethamine into the suprachoroidal space. Electroretinography results demonstrated no abnormal changes in rod cell response, maximum rod cell or cone cell mixing reaction, oscillation potential, cone cell response, waveform, amplitude, and potential of 30 Hz scintillation response in right eyes before injection, and at 1, 2, and 4 weeks after injection. There was no difference between left (control) and right eyes. Under light microscopy, the histomorphology of cells in each retinal layer was normal at 4 weeks following 6 mg ketorolac tromethamine administration. These results indicate that a single suprachoroidal injection of 3 or 6 mg ketorolac tromethamine into rabbits was safe. Suprachoroidal space injection appears to be safe.

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出版当年[2011]版:
大类 | 4 区 医学
小类 | 4 区 细胞生物学 4 区 神经科学
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 细胞生物学 3 区 神经科学
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出版当年[2010]版:
Q4 CELL BIOLOGY Q4 NEUROSCIENCES
最新[2023]版:
Q1 NEUROSCIENCES Q2 CELL BIOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2010版] 出版当年五年平均 出版前一年[2009版] 出版后一年[2011版]

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第一作者机构: [1]Ningxia Med Univ, Gen Hosp, Yinchuan 750004, Ningxia Hui Aut, Peoples R China
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