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Transforming Growth Factor-beta(1) Promotes Nasal Mucosal Mast Cell Chemotaxis in Murine Experimental Allergic Rhinitis

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机构: [1]Beijing Inst Otolaryngol, Key Lab Otolaryngol Head & Neck Surg, Minist Educ, Beijing 100005, Peoples R China [2]Capital Med Univ, Dept Otolaryngol Head & Neck Surg, Beijing TongRen Hosp, Beijing, Peoples R China [3]Univ Yamanashi, Dept Immunol, Fac Med, Yamanashi, Japan
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关键词: Transforming growth factor-beta(1) Mast cells RhoA Allergic rhinitis

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Background: Recent studies have shown that transforming growth factor-beta(1) (TGF-beta(1)) plays an important role in the progression of allergic diseases. Methods: Mouse models of allergic rhinitis were established by ovalbumin sensitization and challenge. Immunostaining was used to analyze the expression of TGF-beta(1) in the mouse nasal mucosa. A chemotaxis assay was conducted to analyze the impact of TGF-beta(1) stimulation on migration of mast cells differentiated from mouse bone marrow cells. Chemotaxis and Western blot analysis were further applied to investigate the pathways involved in mast cell migration induced by TGF-beta(1) stimulation. Results: TGF-beta(1) expression was induced in allergic rhinitis and phosphorylated Smad2 was expressed in mast cells present in the nasal mucosa. TGF-beta(1) could induce migration of mast cells, but HTS466284, a TGF-beta receptor 1 kinase inhibitor, inhibited this chemotactic activity. After TGF-beta(1) stimulation, mast cell RhoA expression was significantly increased. TGF-beta(1)-induced mast cell chemotaxis could be inhibited by the RhoA inhibitor Tat-C3 and myosin light chain kinase inhibitor ML-7. Conclusion: TGF-beta(1) plays a major role in inducing the accumulation of mast cells in allergic rhinitis. Copyright (c) 2012 S. Karger AG, Basel

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出版当年[2011]版:
大类 | 4 区 医学
小类 | 4 区 耳鼻喉科学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 耳鼻喉科学
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出版当年[2010]版:
Q3 OTORHINOLARYNGOLOGY
最新[2023]版:
Q2 OTORHINOLARYNGOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2010版] 出版当年五年平均 出版前一年[2009版] 出版后一年[2011版]

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第一作者机构: [1]Beijing Inst Otolaryngol, Key Lab Otolaryngol Head & Neck Surg, Minist Educ, Beijing 100005, Peoples R China
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通讯机构: [1]Beijing Inst Otolaryngol, Key Lab Otolaryngol Head & Neck Surg, Minist Educ, Beijing 100005, Peoples R China [2]Capital Med Univ, Dept Otolaryngol Head & Neck Surg, Beijing TongRen Hosp, Beijing, Peoples R China [*1]Beijing Inst Otolaryngol, Key Lab Otolaryngol Head & Neck Surg, Minist Educ, 17 HouGouHuTong, Beijing 100005, Peoples R China
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