机构:[1]Center Lab of Beijing Tongren Hospital, Capital Medical University, Beijing, China 首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Otolaryngology-Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Bejing, China 北京朝阳医院[3]Department of Otolaryngology-Head & Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Bejing, China临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Background: To examine changes of chemical sensory functions in patients with dysosmia. Material/Methods: The 272 study subjects included 98 healthy volunteers, 86 subjects with hyposmia and 88 subjects with functional anosmia. Their chemical sensory functions were examined using olfactory event-related potentials (oERPs), trigeminal event-related potentials (tERPs), T&T olfactometer and triple drop method, respectively. Results: The T&T results showed that the difference between patients and healthy subjects had statistical significance. The oERPs and tERPs results showed that patients with functional anosmia had N1 and P2 waves of prolonged latency and reduced amplitude when compared to healthy subjects with the difference of statistical significance. When compared to healthy subjects, patients with functional anosmia had clear hypogeusia and the difference had statistical significance. For the younger group there was significant difference between healthy subjects and patients in T&T, oERPs and tERPs results. Conclusions: It is suggested by the apparently concomitant trigeminal nerve dysfunction and hypogeusia in patients with functional anosmia in this study that olfactory and nasal trigeminal function in young patients was clearly decreased. Our study suggests the possible application of oERPs, tERPs and three drops method in clinical diagnosis in Chinese populations and provides scientific evidence for treatment.
基金:
China Natural Scientific FoundationNational Natural Science Foundation of China (NSFC) [30973284]; Capital Medical Development Foundation [2007-1034]
第一作者机构:[1]Center Lab of Beijing Tongren Hospital, Capital Medical University, Beijing, China
通讯作者:
推荐引用方式(GB/T 7714):
Yang Ling,Wei Yongxiang,Zhang Wei,et al.Examination of chemosensory functions in patients with dysosmia[J].MEDICAL SCIENCE MONITOR.2012,18(3):CR154-CR159.doi:10.12659/MSM.882520.
APA:
Yang, Ling,Wei, Yongxiang,Zhang, Wei,Ren, Yuanyuan,Yu, Di...&Zhang, Jinfeng.(2012).Examination of chemosensory functions in patients with dysosmia.MEDICAL SCIENCE MONITOR,18,(3)
MLA:
Yang, Ling,et al."Examination of chemosensory functions in patients with dysosmia".MEDICAL SCIENCE MONITOR 18..3(2012):CR154-CR159