Objective: Interleukin-1 receptor-associated kinase-4 (IRAK-4) encodes a kinase that is essential for NF-kB activation in Toll-like receptor and T-cell receptor signaling pathways, indicating a possible crosstalk between innate and acquired immunities. We attempted to determine whether the polymorphisms in the Interleukin-1 receptor-associated kinase-4 (IRAK-4) gene are associated with allergic rhinitis (AR) in the Han Chinese population. Methods: A population of 379 patients with AR and 333 healthy controls was studied. Blood was drawn for DNA extraction and total serum immunoglobulin E (IgE). A total of 11 single nucleotide polymorphisms (SNPs) in IRAK-4 were selected and individually genotyped. Results: Significant allelic differences between cases and controls were obtained for the SNP of rs3794262 in the IRAK-4 gene. In the stratified analysis for gender, two SNPs (rs4251431 and rs6582484) in males appeared as significant associations. Subgroup analysis for the presence of different allergen sensitivities displayed associations only in the house dust mite-allergic cohorts (rs3794262, rs4251481). None of the selected SNPs in IRAK-4 was associated with total IgE level. The haplotype analyisis indicated GCCTGCGA was significantly associated with AR. The SNP-SNP interaction information analysis indicated that the selected sets of polymorphisms had no synergistic effect. Conclusions: Our findings did not support the potential contribution of the IRAK-4 gene to serum IgE levels. However, the results demonstrated a gender-and allergen-dependant association pattern between polymorphisms in IRAK-4 and AR in Chinese population.
基金：
National Science Fund for Distinguished Young ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [81025007]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30872846, 30973282]; Beijing Science and Technology Program [KZ200910025008]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7072017]; Special Fund of Sanitation Elite Reconstruction of Beijing [2009-2-007]
第一作者机构：[1]Beijing Inst Otorhinolaryngol, Key Lab Otolaryngol Head & Neck Surg, Minist Educ China, Beijing, Peoples R China[2]Capital Med Univ, Dept Otolaryngol Head & Neck Surg, Beijing TongRen Hosp, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Beijing Inst Otorhinolaryngol, Key Lab Otolaryngol Head & Neck Surg, Minist Educ China, Beijing, Peoples R China[2]Capital Med Univ, Dept Otolaryngol Head & Neck Surg, Beijing TongRen Hosp, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Yuan,Lin Xiaoping,Desrosiers Martin,et al.Association Pattern of Interleukin-1 Receptor-Associated Kinase-4 Gene Polymorphisms with Allergic Rhinitis in a Han Chinese Population[J].PLOS ONE.2011,6(6):doi:10.1371/journal.pone.0021769.
APA：
Zhang, Yuan,Lin, Xiaoping,Desrosiers, Martin,Zhang, Wei,Meng, Na...&Zhang, Luo.(2011).Association Pattern of Interleukin-1 Receptor-Associated Kinase-4 Gene Polymorphisms with Allergic Rhinitis in a Han Chinese Population.PLOS ONE,6,(6)
MLA：
Zhang, Yuan,et al."Association Pattern of Interleukin-1 Receptor-Associated Kinase-4 Gene Polymorphisms with Allergic Rhinitis in a Han Chinese Population".PLOS ONE 6..6(2011)
