Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population
机构：[1]Department of Otolaryngology and Head and Neck Surgery, Affiliated Beijing Tongren Hospital, Capital University of Medical Sciences, Key Laboratoryof Otolaryngology and Head and Neck Surgery, Ministry of Education, Dongjiao Minxiang Street, DongCheng District, Beijing 100730, China 临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021, China
The purpose of this study was to examine whether functional polymorphisms in the cytochrome P450 (CYP) enzyme genes affect the risk of developing larynx and hypopharynx squamous cell carcinoma (SCC). We investigated CYP1A1, CYP1B1, CYP2E1, and CYP3A4 polymorphisms in 278 patients with laryngeal and hypopharyngeal SCC and 278 control subjects by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Subjects with the CYP1A1 3798CC or TC genotype had an odds ratio (OR) of 3.26 (95% confidence interval CI = 1.76-6.03) or 1.56 (95% CI = 1.06-2.31), compared with those with the TT genotype. An increased risk was also associated with the CYP1A1 462Val/Val genotype (OR = 2.39, 95% CI = 1.11-5.16), compared with the TT genotype. Haplotype analysis suggested a synergistic effect of these two polymorphisms. A multipli- cative joint effect between the CYP1A1 3798 T > C polymorphism and smoking was observed. The OR (95% CI) of the TC or CC genotype for nonsmokers and smokers of >20 pack-years were 1.85 (0.99-3.44) or 8.15 (4.35-15.26), respectively (P-trend < 0.05). The CYP1A1 single-nucleotide polymorphisms are associated with an increased risk of developing smoking-related laryngeal and hypopharyngeal SCC in a Han Chinese population. (C) 2010 Elsevier Inc. All rights reserved.
第一作者机构：[1]Department of Otolaryngology and Head and Neck Surgery, Affiliated Beijing Tongren Hospital, Capital University of Medical Sciences, Key Laboratoryof Otolaryngology and Head and Neck Surgery, Ministry of Education, Dongjiao Minxiang Street, DongCheng District, Beijing 100730, China
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推荐引用方式(GB/T 7714)：
Tai Jun,Yang Ming,Ni Xin,et al.Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population[J].CANCER GENETICS AND CYTOGENETICS.2010,196(1):76-82.doi:10.1016/j.cancergencyto.2009.08.015.
APA：
Tai, Jun,Yang, Ming,Ni, Xin,Yu, Dianke,Fang, Jugao...&Han, Demin.(2010).Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population.CANCER GENETICS AND CYTOGENETICS,196,(1)
MLA：
Tai, Jun,et al."Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population".CANCER GENETICS AND CYTOGENETICS 196..1(2010):76-82
