Akt mediates survival signals which preserve various cancer cells from apoptosis. Its correlation with chemoresistance of cancer cells has attracted much attention. But how Akt affects vincristine-induced cell death in retinoblastoma is unknown. Here we show that Akt activity is involved in vincristine-induced cytotoxicity in retinoblastoma SO-Rb50 cells. Inhibition of Akt can decrease the survival of both sensitive and vincristine-resistant SO-Rb50 cells and increase the sensitivity of both cell lines to vincristine by enhancing the cell apoptosis and increasing the cellular accumulation of the drug. Akt may be a target for reducing drug resistance that improves the treatment for retinoblastoma.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30772377, 2008]
第一作者机构：[1]Capital Med Univ, Beijing Tong Ren Hosp, Beijing Tong Ren Eye Ctr, Beijing Inst Ophthalmol, Beijing 100005, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tong Ren Hosp, Beijing Tong Ren Eye Ctr, Beijing Inst Ophthalmol, Beijing 100005, Peoples R China[*1]Capital Med Univ, Beijing Tong Ren Hosp, Beijing Tong Ren Eye Ctr, Beijing Inst Ophthalmol, Hougou Lane 17,Chong Nei St, Beijing 100005, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Hao,Li Bin,Bai Shu-wei,et al.Constitutively Active Akt Contributes to Vincristine Resistance in Human Retinoblastoma Cells[J].CANCER INVESTIGATION.2010,28(2):156-165.doi:10.3109/07357900903179641.
APA：
Zhang, Hao,Li, Bin,Bai, Shu-wei&Wang, Hui-juan.(2010).Constitutively Active Akt Contributes to Vincristine Resistance in Human Retinoblastoma Cells.CANCER INVESTIGATION,28,(2)
MLA：
Zhang, Hao,et al."Constitutively Active Akt Contributes to Vincristine Resistance in Human Retinoblastoma Cells".CANCER INVESTIGATION 28..2(2010):156-165
