BACKGROUND AND OBJECTIVE: To assess the agreement of the Pentacam (Oculus, Wetzlar, Germany) and anterior-segment optical coherence tomography (AS-OCT) in measuring open and narrow angles. PATIENTS AND METHODS: Prospective observational case series in which 39 healthy normal subjects (39 eyes) and 25 patients with narrow angles (37 eyes) were enrolled between May and September 2008. The anterior chamber measurements were performed by AS-OCT and the Pentacam. RESULTS: There was no significant difference in the open-angle measurements between the Pentacam and AS-OCT (P > .05). However, in patients with narrow angles, the average values of nasal and temporal anterior chamber angles taken by the Pentacam were larger than those of AS-OCT (25.5 degrees +/- 5.66 degrees and 25.77 degrees +/- 5.15 degrees vs 13.40 degrees +/- 6.81 degrees and 12.13 degrees +/- 6.47 degrees; P < .001). CONCLUSION: Both AS-OCT and the Pentacam can reliably measure anterior chamber angles in healthy normal subjects. The difference in measuring narrow angles by the two instruments was due to inability to view the angle recess or the scleral spur with the Pentacam.