机构：[1]School of Materials Science and Engineering, University of Science and Technology Beijing 100083, China[2]Department of Ophthalmology, Tongren Hospital, Capital Medical University, Beijing, China临床科室眼科眼科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tian Jin 300071, China
Injectable acrylamide/N-vinylpyrrolidinone copolymers with pendent thiol groups were prepared by a radical polymerization and reductive dissolution reaction. The solution of copolymers was re-gelled through oxidation in air or the thiol-disulfide exchange reaction. The re-gelation time could be adjusted from several minutes to several hours by changing the amount of the disulfide exchange reagent. The re-gelled hydrogels possessed high transmittance in the visible region but could block out some of the ultraviolet radiation. Their refractive indexes ranged from 1.34 to 1.35, and their equilibrium water contents were over 95.0%. The morphologies of the hydrogels were analyzed and the porous structure, with pore sizes of 50-300 mu m, was noted. The cytotoxicities of the hydrogels were clearly reduced compared with previous results. The experimental results indicated that the injectable copolymers could be used as an artificial vitreous substance or as a scaffold for lens regeneration. (C) 2009 Published by Elsevier Ltd. on behalf of Acta Materialia Inc.
基金：
Chinese National Science and Technology Supporting Item [2006BAI03A09]
第一作者机构：[1]School of Materials Science and Engineering, University of Science and Technology Beijing 100083, China
通讯作者：
推荐引用方式(GB/T 7714)：
Niu Guoguang,Yang Ying,Zhang Hongbin,et al.Synthesis and characterization of acrylamide/N-vinylpyrrolidone copolymer with pendent thiol groups for ophthalmic applications[J].ACTA BIOMATERIALIA.2009,5(4):1056-1063.doi:10.1016/j.actbio.2008.10.015.
APA：
Niu, Guoguang,Yang, Ying,Zhang, Hongbin,Yang, Jun,Song, Li...&Yang, Huai.(2009).Synthesis and characterization of acrylamide/N-vinylpyrrolidone copolymer with pendent thiol groups for ophthalmic applications.ACTA BIOMATERIALIA,5,(4)
MLA：
Niu, Guoguang,et al."Synthesis and characterization of acrylamide/N-vinylpyrrolidone copolymer with pendent thiol groups for ophthalmic applications".ACTA BIOMATERIALIA 5..4(2009):1056-1063
医学