机构：[1]Capital Med Univ, Key Lab Otolaryngol Head & Neck Surg, Minist Educ China, Beijing Inst Otorhinolaryngol, Beijing, Peoples R China研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing, Peoples R China临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Inner Mongolia Med Coll, Hohhot, Inner Mongolia, Peoples R China
Conclusion. The results of our study demonstrated the association between the single nucleotide polymorphisms (SNPs) of GATA-3 and allergic rhinitis (AR). Objective. AR is considered to be controlled by T-helper type 2 (Th2) cells. GATA-3 is the crucial transcription factor controlling the differentiation and function of Th2 cells. We aimed to evaluate the association between the SNPs of GATA-3 and AR. Subjects and methods. GATA-3 SNPs in 109 AR patients and 112 healthy controls in China were detected with restriction fragment length polymorphism. Results. The genotypes at rs1269486 were GG, GA, and AA, and the genotypes at rs2229360 were CC, CT, and TT. The frequency of the G allele in the patient group was significantly higher than that in the control group (p0.01), while the frequency of the A allele in the patient group was significantly lower than that in the control group (p0.01). Meanwhile, the haplotype frequency of GC at the two loci in the patient group was significantly higher than that in the control group (p0.01), and the haplotype frequency of AC in the patient group was significantly lower than that in the control group (p0.01).
基金：
National Key Technology R&D Program from the Ministry of Science and Technology of PR ChinaNational Key Technology R&D Program [2007BAI18 B15]; Beijing Science and Technology Program [Z0005190041531]
第一作者机构：[1]Capital Med Univ, Key Lab Otolaryngol Head & Neck Surg, Minist Educ China, Beijing Inst Otorhinolaryngol, Beijing, Peoples R China[2]Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, Key Lab Otolaryngol Head & Neck Surg, Minist Educ China, Beijing Inst Otorhinolaryngol, Beijing, Peoples R China[2]Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Luo,Wang Xiangdong,Han Demin,et al.Association of single nucleotide polymorphisms in GATA-3 with allergic rhinitis[J].ACTA OTO-LARYNGOLOGICA.2009,129(2):190-194.doi:10.1080/00016480802139846.
APA：
Zhang, Luo,Wang, Xiangdong,Han, Demin,Duan, Hong&Zhao, Yan.(2009).Association of single nucleotide polymorphisms in GATA-3 with allergic rhinitis.ACTA OTO-LARYNGOLOGICA,129,(2)
MLA：
Zhang, Luo,et al."Association of single nucleotide polymorphisms in GATA-3 with allergic rhinitis".ACTA OTO-LARYNGOLOGICA 129..2(2009):190-194
