Purpose: The aim of this study was to determine the pharmacokinetic parameters of chlorhexidine gluconate (CHG) in the rabbit cornea. Methods: Each eye of 16 New Zealand white rabbits were topically instilled with 50 mu L of CHG 0.02% eye drops twice with a 5-min interval. Four (4) corneas of 2 rabbits were harvested at each time point. The concentration of CHG in the cornea was determined with high-performance liquid chromatography, (HPLC) and 387 software to simulate the pharmacokinetic parameters. Results: The concentration of CHG in the cornea displayed an open two-compartment model. T-max was 13.75 min, C-max 0.713 ug (.) g(-1), clearance rate 1.64 ug (.) g(-1) (.) min(-1), and t(1/2 alpha), t(1/2 beta), and t(1/2ka) was 2.65, 48.72, and 2.67 min, respectively. Conclusions: The concentration of CHG in the rabbit cornea could be determined by means of HPLC. The maximum concentration of CHG in the corneal tissue was much higher than the trophozoite minimum amoebicidal concentration (TMAC) in vitro.
第一作者机构：[1]Beijing Tongren Hosp, Beijing Inst Ophthalmol, Dept Ocular Microbiol, Beijing 100005, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Sun Xuguang,Liang Yanchuang,Zhang Feng,et al.Pharmacokinetics of chlorhexidine gluconate 0.02% in the rabbit cornea[J].JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS.2006,22(4):227-230.doi:10.1089/jop.2006.22.227.
APA：
Sun Xuguang,Liang Yanchuang,Zhang Feng,Luo Shiyun&Yin Xiaotang.(2006).Pharmacokinetics of chlorhexidine gluconate 0.02% in the rabbit cornea.JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS,22,(4)
MLA：
Sun Xuguang,et al."Pharmacokinetics of chlorhexidine gluconate 0.02% in the rabbit cornea".JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS 22..4(2006):227-230
