机构：[1]Otology Skull Base Surgery Department, Hearing Research Institute[2]Central Laboratory, Eye and ENT Hospital of Shanghai Medical School[3]Children’s Hospital of Fudan University, Fudan University, Shanghai[4]Department of Otolaryngology Head & Neck Surgery, BeijingTongren Hospital, A⁄liated Capital Medical Science University, Beijing,PR China首都医科大学附属同仁医院[5]Department of Otolaryngology and Program in Neuroscience, Harvard Medical School[6]Eaton Peabody Laboratory, Massachusetts Eye and Ear In¢rmary, Boston, Massachussetts,USA
Sonic hedgehog (Shh) signaling is essential for auditory cell fate determination and inner ear dorsal/ventral patterning during development. Here, we show that Shh accelerates inner ear progenitor cell proliferation, and the inhibitor of Shin signaling cycloparnine reduces mitotic growth of otocyst cells in vitro. The number of hair cells in cultures of inner ear progenitor cells that were treated with Shh was significantly higher than that in control cultures. When Shh signaling was blocked with cycloparnine, hair cell generation was largely inhibited. Our results suggest that Shh may be a regulator of inner ear progenitor cell growth and hair cell generation.
基金：
Grant 30525038 (H.L.) from the National Nature Science Foundation of China, and grant 04JCI4094 (H.L.)from the Shanghai Science and Technology Committee
第一作者机构：[1]Otology Skull Base Surgery Department, Hearing Research Institute[4]Department of Otolaryngology Head & Neck Surgery, BeijingTongren Hospital, A⁄liated Capital Medical Science University, Beijing,PR China
共同第一作者：
通讯作者：
通讯机构：[1]Otology Skull Base Surgery Department, Hearing Research Institute[2]Central Laboratory, Eye and ENT Hospital of Shanghai Medical School[5]Department of Otolaryngology and Program in Neuroscience, Harvard Medical School[6]Eaton Peabody Laboratory, Massachusetts Eye and Ear In¢rmary, Boston, Massachussetts,USA[*1]Fudan Univ, Eye & ENT Hosp, Shanghai Med Sch, Cent Lab, 83 Fenyang Rd, Shanghai 200031, Peoples R China
推荐引用方式(GB/T 7714)：
Zhao YL,Wang YC,Wang ZM,et al.Sonic hedgehog promotes mouse inner ear progenitor cell proliferation and hair cell generation in vitro[J].NEUROREPORT.2006,17(2):121-124.doi:10.1097/01.wnr.0000198439.44636.49.
