机构：[1]Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan[2]Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki, Japan[3]Department of Internal Medicine, Mitsubishi Mihara Hospital, Mihara, Japan[4]Department of Internal Medicine, National Hospital Organization Higashihiroshima Medical Center, Higashihiroshima, Japan[5]Department of Internal Medicine, Shobara Red Cross Hospital, Shobara, Japan[6]Department of Internal Medicine, Akitsu Prefectural Hospital, Hiroshima, Japan[7]Department of Internal Medicine, Hiroshima Prefectural Hospital, Hiroshima, Japan[8]Department of Internal Medicine, Saiseikai Hiroshima Hospital, Hiroshima, Japan[9]Department of Internal Medicine, Hiroshima Asa-city Hospital, Hiroshima, Japan[10]Division of Digestive Disease, Department of Internal Medicine, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing, China临床科室内科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[11]Department of Medicine and Molecular Science, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
Aim: We investigated the effect of acid suppression therapy on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer. Methods: A total of 400 patients with bleeding peptic ulcer received either intravenous infusion of famotidine (40 mg/day) (n = 207, 163 males, 44 females, mean age 61.5 years) or drip infusion of omeprazole (40 mg/ day; n = 193, 134 males, 59 females, mean age 59.8 years) after successful endoscopic treatment. The fasting duration, hospital stay, volume of transfused blood, incidence of rebleeding and mortality were compared between the two groups. Results: The incidence of rebleeding did not differ significantly between the famotidine group (9%) and the omeprazole group (8%). The mean hospital stay was significantly shorter in the omeprazole group (18.4 days) than in the famotidine group (21.5 days, P = 0.009). However, there was no statistically significant difference in fasting duration, volume of transfused blood or mortality. Conclusion: Our findings indicate that intravenous infusion of famotidine after successful endoscopic treatment is equivalent to drip infusion of omeprazole for prevention of recurrent bleeding.
第一作者机构：[1]Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan
通讯作者：
推荐引用方式(GB/T 7714)：
Kamada T,Hata J,Kusunoki H,et al.Effect of famotidine on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer[J].ALIMENTARY PHARMACOLOGY & THERAPEUTICS.2005,21:73-78.doi:10.1111/j.1365-2036.2005.02478.x.
APA：
Kamada, T,Hata, J,Kusunoki, H,Kido, S,Hamada, H...&Haruma, K.(2005).Effect of famotidine on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer.ALIMENTARY PHARMACOLOGY & THERAPEUTICS,21,
MLA：
Kamada, T,et al."Effect of famotidine on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer".ALIMENTARY PHARMACOLOGY & THERAPEUTICS 21.(2005):73-78
医学