Objective To evaluate the possible relationship between insulin-like growth factor-1 (IGF-1) and diabetic neuropathy (DNP). Methods Sixty-nine patients with Type 2 non-insulin-dependent diabetes (54 with peripheral neuropathy and 15 without neuropathy) were observed. Normal controls were 34 non-diabetic persons. Diabetic peripheral neuropathy diagnosis was carried out taking into account results of NS, ND, NC and AF. After an overnight fast, blood was taken for IGF-1, glucose, hemoglobin Alc, C-peptide, and insulin. Plasma IGF-1 was measured by radioimmunoassay (RIA) method. Results The neuropathic group had significantly lower levels for IGF-1 (86.43 ng/ml +/- 45.18 ng/ml) compared to normal controls (119.68 ng/ml +/- 89.42 ng/ml) (P < 0.05), and to diabetic patients without neuropathy (113.75 ng/ml +/- 66.58 ng/ml) (P < 0.05). No significant difference was found between diabetic non-neuropathic group and normal control subjects (P > 0.05). In diabetic subjects there was a positive correlation (gamma = 0.27, P < 0.05) between IGF-1 and beat to variation in heart rate. There were negative correlation between IGF-1 and postprandial blood glucose (gamma = -0.3, p < 0.05), and aspartic acid translocase (gamma = - 0.27, P < 0.05). Conclusion In diabetic patients with peripheral neuropathy there are abnormalities of IGF-1 that may contribute to the pathogeneses of diabetic neuropathy.
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Neurol, Beijing 100730, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Guo HL,Yang Y,Geng ZP,et al.The change of insulin-like growth factor-1 in diabetic patients with neuropathy[J].CHINESE MEDICAL JOURNAL.1999,112(1):76-79.
APA：
Guo, HL,Yang, Y,Geng, ZP,Zhu, LX,Yuan, SY...&Fu, HJ.(1999).The change of insulin-like growth factor-1 in diabetic patients with neuropathy.CHINESE MEDICAL JOURNAL,112,(1)
MLA：
Guo, HL,et al."The change of insulin-like growth factor-1 in diabetic patients with neuropathy".CHINESE MEDICAL JOURNAL 112..1(1999):76-79
