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Cancer increases risk of in-hospital death from COVID-19 in persons <65 years and those not in complete remission (Open Access)

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收录情况： ◇ SCIE

作者：
Qiubai Li [1] * ; Lei Chen[1] * ; Qin Li[2] * ; Wenjuan He[1] ; Jianming Yu[1] ; Li Chen[3] ; Yulin Cao[1] ; Wenlan Chen[1] ; Di Wu[1] ; Fang Dong[4] ; Liling Cai[5] ; Qijie Ran[6] ; Lei Li[7] ; Qiaomei Liu[8] ; Wenxiang Ren[1] ; Fei Gao[1] ; Hongxiang Wang[3] ; Zhichao Chen[1] ; Robert Peter Gale[9] ; Yu Hu [1] ;
机构： [1]Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China [2]Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China [3]Department of Hematology, Wuhan Central Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [4]Intensive Care Units of Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, China [5]Department of Urology Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China [6]Department of Hematology, General Hospital of Central Theater Command, PLA, Wuhan, 300700, China [7]Wuhan Jin-Yin-Tan Hospital, Wuhan, China [8]Medical Records Statistics Department of Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, China [9]Center for Hematology Research, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
出处：
DOI： 10.1038/s41375-020-0986-7
ISSN：

摘要：
The impact of cancer on outcome of persons with coronavirus disease 2019 (COVID-19) after infection with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is controversial. We studied 1859 subjects with COVID-19 from seven centers in Wuhan, China, 65 of whom had cancer. We found having cancer was an independent risk factor for in-hospital death from COVID-19 in persons <65 years (hazard ratio [HR] = 2.45, 95% confidence interval [CI], 1.04, 5.76; P = 0.041) but not in those ≥65 years (HR = 1.12 [0.56, 2.24]; P = 0.740). It was also more common in those not in complete remission. Risks of in-hospital death were similar in subjects with solid cancers and those with hematological cancers. These data may help predict outcomes of persons with cancer and COVID-19. © 2020, The Author(s), under exclusive licence to Springer Nature Limited.

基金：
Acknowledgements We thank participating patients, families and health care providers. Supported by the National Natural Science Foundation of China (81974009 to QL and 81974221 to ZC) and the Fundamental Research Funds for the Central Universities (2020kfyXGYJ086 to QL). RPG acknowledges support from the National Institute of Health Research (NIHR) Biomedical Research Centre funding scheme.
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外文
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出版当年[2019]版：
大类 | 1 区 医学
小类 | 1 区 血液学 1 区 肿瘤学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 血液学 1 区 肿瘤学
JCR分区：
出版当年[2018]版：
Q1 ONCOLOGY Q1 HEMATOLOGY
最新[2023]版：
Q1 ONCOLOGY Q1 HEMATOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Qiubai Li,Lei Chen,Qin Li,et al.Cancer increases risk of in-hospital death from COVID-19 in persons &lt;65 years and those not in complete remission (Open Access)[J].LEUKEMIA.2020,34(9):2384-2391.doi:10.1038/s41375-020-0986-7.
APA：
Qiubai Li,Lei Chen,Qin Li,Wenjuan He,Jianming Yu...&Yu Hu.(2020).Cancer increases risk of in-hospital death from COVID-19 in persons &lt;65 years and those not in complete remission (Open Access).LEUKEMIA,34,(9)
MLA：
Qiubai Li,et al."Cancer increases risk of in-hospital death from COVID-19 in persons &lt;65 years and those not in complete remission (Open Access)".LEUKEMIA 34..9(2020):2384-2391

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