高级检索
当前位置: 首页 > 详情页

Identification of type 2 diabetes loci in 433,540 East Asian individuals

文献详情

资源类型:
WOS体系:
Pubmed体系:

收录情况: ◇ SCIE ◇ 自然指数

作者:
机构: [1]Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA [2]Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Biostat & Epidemiol, Amherst, MA 01003 USA [3]RIKEN Ctr Integrat Med Sci, Lab Endocrinol Metab & Kidney Dis, Yokohama, Kanagawa, Japan [4]Natl Inst Hlth, Div Genome Res, Ctr Genome Sci, Osong Eup, Chungcheongbuk, South Korea [5]Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England [6]RIKEN Ctr Integrat Med Sci, Lab Stat & Translat Genet, Yokohama, Kanagawa, Japan [7]Univ Tokyo, Grad Sch Med, Dept Diabet & Metab Dis, Tokyo, Japan [8]Osaka Univ, Dept Stat Genet, Grad Sch Med, Osaka, Japan [9]Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China [10]Chinese Univ Hong Kong, Chinese Univ Hong Kong Shanghai Jiao Tong Univ Jo, Hong Kong, Peoples R China [11]Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan [12]Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea [13]Natl Ctr Global Hlth & Med, Res Inst, Dept Gene Diagnost & Therapeut, Tokyo, Japan [14]Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Nashville, TN USA [15]Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore [16]Natl Univ Hlth Syst, Singapore, Singapore [17]Acad Sinica, Inst Biomed Sci, Taipei, Taiwan [18]Nagoya Univ, Dept Integrated Hlth Sci, Grad Sch Med, Nagoya, Aichi, Japan [19]Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA [20]Univ Calif Los Angeles, Sch Med, Dept Pediat, Harbor UCLA Med Ctr, Torrance, CA 90509 USA [21]Hallym Univ, Biomed Sci, Chunchon, South Korea [22]Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England [23]Univ Oxford, Wellcome Ctr Human Genet, Oxford, England [24]Oxford Univ Hosp NHS Fdn Trust, Churchill Hosp, Oxford NIHR Biomed Res Ctr, Oxford, England [25]Vanderbilt Univ, Med Ctr, Div Med Genet, Vanderbilt Genet Inst, Nashville, TN USA [26]Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Human Genet Ctr, Houston, TX 77030 USA [27]Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA [28]Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA [29]Wake Forest Sch Med, Ctr Genom & Personalized Med Res, Ctr Diabet Res, Winston Salem, NC 27101 USA [30]Wake Forest Sch Med, Dept Biochem, Winston Salem, NC 27101 USA [31]Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore [32]Imperial Coll London, Dept Epidemiol & Biostat, London, England [33]London North West Healthcare NHS Trust, Ealing Hosp, Dept Cardiol, London, England [34]Imperial Coll London, Imperial Coll Healthcare NHS Trust, London, England [35]Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England [36]Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England [37]Univ Manchester, Sch Biol Sci, Manchester, Lancs, England [38]Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC 27515 USA [39]RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan [40]Kyushu Univ, Grad Sch Med Sci, Dept Ophthalmol, Fukuoka, Japan [41]Chinese Acad Med Sci, Beijing, Peoples R China [42]Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China [43]Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China [44]Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore [45]Natl Taiwan Univ Hosp, Dept Internal Med, Div Endocrinol Metab, Taipei, Taiwan [46]Natl Taiwan Univ, Sch Publ Hlth, Inst Prevent Med, Taipei, Taiwan [47]Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA [48]Univ N Carolina, Gillings Sch Global Publ Hlth, Carolina Populat Ctr, Dept Biostat, Chapel Hill, NC 27515 USA [49]Chinese Natl Human Genome Ctr Shanghai, Shanghai MOST Key Lab Hlth & Dis Genom, Dept Genet, Shanghai, Peoples R China [50]Tri Serv Gen Hosp Songshan Branch, Div Endocrine & Metab, Taipei, Taiwan [51]Natl Def Med Ctr, Sch Med, Taipei, Taiwan [52]Taipei Vet Gen Hosp, Dept Med, Sect Endocrinol & Metab, Taipei, Taiwan [53]Natl Yang Ming Univ, Sch Med, Taipei, Taiwan [54]Jichi Med Univ, Sch Med, Dept Environm & Prevent Med, Shimotsuke, Tochigi, Japan [55]Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Mannheim, Germany [56]Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Lab Complex Trait Genom, Tokyo, Japan [57]Osaka Univ, Dept Clin Gene Therapy, Grad Sch Med, Osaka, Japan [58]Osaka Univ, Grad Sch Med, Dept Geriatr & Gen Med, Osaka, Japan [59]Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore [60]Ehime Univ, Fac Collaborat Reg Innovat, Dept Reg Resource Management, Matsuyama, Ehime, Japan [61]Yonsei Univ, Coll Med, Severance Biomed Sci Inst, Seoul, South Korea [62]Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea [63]Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea [64]Univ San Carlos, Dept Anthropol Sociol & Hist, Cebu, Philippines [65]Peking Univ, Peking Univ Hlth Sci Ctr, Dept Epidemiol & Biostat, Beijing, Peoples R China [66]Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore [67]Osaka Univ, Immunol Frontier Res Ctr WPI IFReC, Lab Stat Immunol, Osaka, Japan [68]Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA [69]Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore [70]Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore [71]Natl Cerebral & Cardiovasc Ctr, Dept Genom Med, Osaka, Japan [72]Macau Univ Sci & Technol, Fac Med, Macau, Peoples R China [73]China Med Univ Hosp, Dept Med Genet & Med Res, Taichung, Taiwan [74]Shanghai Jiao Tong Univ, State Key Lab Oncogene & Related Genes, Shanghai Canc Inst, Renji Hosp,Sch Med, Shanghai, Peoples R China [75]Shanghai Jiao Tong Univ, Dept Epidemiol, Shanghai Canc Inst, Renji Hosp,Sch Med, Shanghai, Peoples R China [76]Kurume Univ, Sch Med, Dept Med Biochem, Kurume, Fukuoka, Japan [77]Univ Pittsburgh, UPMC Hillman Canc Ctr, Div Canc Control & Populat Sci, Pittsburgh, PA USA [78]Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA [79]Ehime Univ, Grad Sch Med, Dept Antiaging Med, Matsuyama, Ehime, Japan [80]Capital Med Univ, Beijing Tongren Hosp, Ophthalmol & Visual Sci Key Lab, Beijing Inst Ophthalmol, Beijing, Peoples R China [81]Taichung Vet Gen Hosp, Dept Med, Div Endocrinol & Metab, Taichung, Taiwan [82]Kurume Univ, Sch Med, Kurume, Fukuoka, Japan [83]Seoul Natl Univ, Depr Internal Med, Coll Med, Seoul, South Korea [84]Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul, South Korea [85]Duke NUS Med Sch, Singapore, Singapore [86]Duke NUS Med Sch, Hlth Serv & Syst Res, Singapore, Singapore [87]Univ Ryukyus, Grad Sch Med, Dept Adv Genom & Lab Med, Okinawa, Japan [88]Univ Ryukyus Hosp, Div Clin Lab & Blood Transfus, Okinawa, Japan [89]Univ Oxford, Med Res Council Populat Hlth Res Unit, Oxford, England [90]Present address:Stanford University, Stanford, CA 94305 USA [91]Present address: Genentech, South San Francisco, CA 94080 USA
出处:
ISSN:

摘要:
Meta-analyses of genome-wide association studies (GWAS) have identified more than 240 loci that are associated with type 2 diabetes (T2D)1,2; however, most of these loci have been identified in analyses of individuals with European ancestry. Here, to examine T2D risk in East Asian individuals, we carried out a meta-analysis of GWAS data from 77,418 individuals with T2D and 356,122 healthy control individuals. In the main analysis, we identified 301 distinct association signals at 183 loci, and across T2D association models with and without consideration of body mass index and sex, we identified 61 loci that are newly implicated in predisposition to T2D. Common variants associated with T2D in both East Asian and European populations exhibited strongly correlated effect sizes. Previously undescribed associations include signals in or near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that affect the differentiation of muscle and adipose cells3. At another locus, expression quantitative trait loci at two overlapping T2D signals affect two genes-NKX6-3 and ANK1-in different tissues4-6. Association studies in diverse populations identify additional loci and elucidate disease-associated genes, biology, and pathways.

基金:
语种:
被引次数:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2019]版:
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
最新[2023]版:
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
JCR分区:
出版当年[2018]版:
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版:
Q1 MULTIDISCIPLINARY SCIENCES

影响因子: 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者:
第一作者机构: [1]Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA [2]Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Biostat & Epidemiol, Amherst, MA 01003 USA
共同第一作者:
通讯作者:
通讯机构: [5]Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England [15]Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore [16]Natl Univ Hlth Syst, Singapore, Singapore [89]Univ Oxford, Med Res Council Populat Hlth Res Unit, Oxford, England
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:21169 今日访问量:0 总访问量:1219 更新日期:2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学附属北京同仁医院 技术支持:重庆聚合科技有限公司 地址:北京市东城区东交民巷1号(100730)