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Determinants of lamina cribrosa depth in healthy Asian eyes: the Singapore Epidemiology Eye Study.

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机构： [1]Glaucoma, Singapore Eye Research Institute, Singapore. [2]Department of Biomedical Engineering, National University of Singapore, Singapore. [3]Biological Science and Medical Engineering, Beihang University, Beijing, China. [4]Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. [5]Ocular Epidemiology Research Group and Data Science, Singapore Eye Research Institute, Singapore. [6]NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK. [7]Optometry and Vision Sciences, Cardiff University, Cardiff, UK

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To investigate the determinants of lamina cribrosa depth (LCD) in healthy eyes of Chinese and Indian Singaporean adults.The optic nerve head (ONH) of the right eye of 1396 subjects (628 Chinese and 768 Indian subjects) was imaged with optical coherence tomography (OCT, Spectralis, Heidelberg, Germany). LCD was defined as the distance from the Bruch's membrane opening (LCD-BMO) or the peripapillary sclera (LCD-PPS) reference plane to the laminar surface. A linear regression model was used to evaluate the relationship between the LCD and its determinants.Both LCDs were significantly different between the two races (LCD-BMO: 421.95 (95% CI 365.32 to 491.79) µm in Chinese vs 430.39 (367.46-509.81) µm in Indians, p=0.021; and LCD-PPS: 353.34 (300.98-421.45) µm in Chinese vs 376.76 (313.39-459.78) µm in Indians, p<0.001). In the multivariable regression analysis, the LCD-PPS of the whole cohort was independently associated with females (β=-31.93, p<0.001), Indians subjects (β=21.39, p=0.004) (Chinese as the reference), axial length (Axl) (β=-6.68, p=0.032), retinal nerve fibre layer thickness (RNFL) (β=0.71, p=0.019), choroidal thickness (ChT) (β=0.41, p<0.001), vertical cup disc ratio (VCDR) (β=24.42, p<0.001) and disc size (β=-60.75, p=0.001). For every 1 year older in age, the LCD-PPS was deeper on average by 1.95 µm in Chinese subjects (p=0.01) but there was no association in Indians subjects (p=0.851).The LCD was influenced by age, gender, race, Axl, RNFL, ChT, VCDR and disc size. This normative LCD database may facilitate a more accurate assessment of ONH cupping using OCT in Asian populations.© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.

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出版当年[2020]版：

大类 | 3 区医学

小类 | 2 区眼科学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区眼科学

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第一作者机构： [1]Glaucoma, Singapore Eye Research Institute, Singapore. [2]Department of Biomedical Engineering, National University of Singapore, Singapore.

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通讯机构： [2]Department of Biomedical Engineering, National University of Singapore, Singapore. [*1]Department of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore

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