机构：[1]Department of Otolaryngology-Head and Neck Surgery, Affiliated Beijing Tongren Hospital of Capital University of Medical Sciences, Beijing 100730.临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
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摘要：
Supraglottic carcinomas of larynx tends to metastasize to cervical lymph nodes. The regular pathological method of diagnosis is easy to have the micrometastasis missed, and serial-sectioning is too difficult be used in the regular pathological examinations. The aim of this study was to evaluate the value of immunohistochemical assay in the detection of micrometastasis.Monoclonal antibodies against cytokeratin (AE1/AE3) were used to detect the cervical lymph nodes of 46 cases (50 sides of neck) of supraglottic carcinoma with pathologically negative findings (pN0).Micrometastases were identified in 13 lymph nodes of 11 cases.It is suggested that the detection of lymph node micrometastases with immunohistochemical method is more sensitive than that of regular pathologic method. It is comparable to serial sectioning. Therefore, It is a valuable clinical method to detect the early lymph node metastasis.
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中文
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第一作者：
第一作者机构：[1]Department of Otolaryngology-Head and Neck Surgery, Affiliated Beijing Tongren Hospital of Capital University of Medical Sciences, Beijing 100730.
推荐引用方式(GB/T 7714)：
Yu Z,Han D,Fan E.Immunohistochemical evaluation of micrometastases to cervical lymph nodes in supraglottic cancer[J].Zhonghua er bi yan hou ke za zhi.1999,34(5):306-8.
