机构：[1]Department of Ophthalmology,Affiliated Tong Ren Hospital,Capital Medical University,Beijing 100730.临床科室眼科首都医科大学附属北京同仁医院首都医科大学附属同仁医院眼科(未分亚科)
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摘要：
To study the immunosuppressive effects of FK-506 on allogeneic transplantation in a rat model.Inbred strain Lou rats were used as recipients, and F344 rats were used as donors. Subconjunctival injection of FK-506 0.1 mg/kg and cyclosporine A (CsA) 3 mg/kg were administered respectively for 2 weeks, and the grafts were inspected by clinical evaluation.The group receiving FK-506 had a significant delay in allograft rejection with mean survival time (22.1 +/- 5.17) days vs. (18.4 +/- 1.4) days for the CsA group and (12.1 +/- 2.13) days for the control group (P < 0.01).It is indicated that FK-506 would be a useful drug to suppress corneal graft rejection.
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中文
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第一作者：
第一作者机构：[1]Department of Ophthalmology,Affiliated Tong Ren Hospital,Capital Medical University,Beijing 100730.
推荐引用方式(GB/T 7714)：
Lü L,Zhang W,Sun X.Experimental studies on the effect of the immunosuppressant FK-506 on penetrating keratoplasty rejection model in rats[J].Chinese Journal of Ophthalmology.1999,35(1):25-8.
